Methods of making l-ornithine phenyl acetate
Disclosed is a process for making L-ornithine phenyl acetate salt (V) comprising: preparing a solution of phenyl acetate salt by mixing a phenyl acetic acid and a base in a solvent; intermixing L-ornithine benzoate with the above solution; isolating a composition comprising L-ornithine phenyl acetat...
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| creator | BEHLING JIM WATT STEPHEN WILLIAM ANDERSON KEITH H FIGINI ATTILIA DOUGAN CHRISTINE HENDERSON MANINI PETER |
| description | Disclosed is a process for making L-ornithine phenyl acetate salt (V) comprising: preparing a solution of phenyl acetate salt by mixing a phenyl acetic acid and a base in a solvent; intermixing L-ornithine benzoate with the above solution; isolating a composition comprising L-ornithine phenyl acetate. The process may include forming an L-ornithine benzoate salt intermediate. The process may also include intermixing a halide salt of L-ornithine with silver phenyl acetate. The present application also relates to various compositions obtained from these processes, including crystalline forms. |
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The process may include forming an L-ornithine benzoate salt intermediate. The process may also include intermixing a halide salt of L-ornithine with silver phenyl acetate. The present application also relates to various compositions obtained from these processes, including crystalline forms.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSESC01D OR C01F ; HUMAN NECESSITIES ; HYGIENE ; INORGANIC CHEMISTRY ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150626&DB=EPODOC&CC=NZ&NR=609191A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150626&DB=EPODOC&CC=NZ&NR=609191A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BEHLING JIM</creatorcontrib><creatorcontrib>WATT STEPHEN WILLIAM</creatorcontrib><creatorcontrib>ANDERSON KEITH H</creatorcontrib><creatorcontrib>FIGINI ATTILIA</creatorcontrib><creatorcontrib>DOUGAN CHRISTINE HENDERSON</creatorcontrib><creatorcontrib>MANINI PETER</creatorcontrib><title>Methods of making l-ornithine phenyl acetate</title><description>Disclosed is a process for making L-ornithine phenyl acetate salt (V) comprising: preparing a solution of phenyl acetate salt by mixing a phenyl acetic acid and a base in a solvent; intermixing L-ornithine benzoate with the above solution; isolating a composition comprising L-ornithine phenyl acetate. The process may include forming an L-ornithine benzoate salt intermediate. The process may also include intermixing a halide salt of L-ornithine with silver phenyl acetate. 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The process may include forming an L-ornithine benzoate salt intermediate. The process may also include intermixing a halide salt of L-ornithine with silver phenyl acetate. The present application also relates to various compositions obtained from these processes, including crystalline forms.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSESC01D OR C01F HUMAN NECESSITIES HYGIENE INORGANIC CHEMISTRY MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Methods of making l-ornithine phenyl acetate |
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