17beta-ALKYL-17alpha-OXY-ESTRATRIENES
Disclosed herein are oestratrienes of general formula (I), wherein the variables are defined in the specification, and the use thereof in in the treatment of oestrogen-dependent disorders. Exemplary compounds include: 11?-fluoro-17?-methyl-7?-[5-[(2R)-2-(6,6,7,7,7-pentafluoroheptyl)-1-pyrrolidinyl]p...
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| creator | LIENAU, PHILIP BOHLMANN, ROLF HUBNER, JAN DENNER, KARSTEN KUNZER, HERMANN KOHR, SILKE WINTERMANTEL, TIM HEINRICH, NIKOLAUS HOFFMANN, JENS KETTSCHAU, GEORG LANG, DIETER GERISCH, MICHAEL SANDER, MICHAEL |
| description | Disclosed herein are oestratrienes of general formula (I), wherein the variables are defined in the specification, and the use thereof in in the treatment of oestrogen-dependent disorders. Exemplary compounds include: 11?-fluoro-17?-methyl-7?-[5-[(2R)-2-(6,6,7,7,7-pentafluoroheptyl)-1-pyrrolidinyl]pentyl]oestra-1,3,5(10)-triene-3,17?-diol; and 11?-fluoro-17?-methyl-7?-[5-[methyl(8,8,9,9,9-pentafluorononyl)amino]pentyl]oestra- 1,3,5(10)-triene-3,17?-diol. |
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Exemplary compounds include: 11?-fluoro-17?-methyl-7?-[5-[(2R)-2-(6,6,7,7,7-pentafluoroheptyl)-1-pyrrolidinyl]pentyl]oestra-1,3,5(10)-triene-3,17?-diol; and 11?-fluoro-17?-methyl-7?-[5-[methyl(8,8,9,9,9-pentafluorononyl)amino]pentyl]oestra- 1,3,5(10)-triene-3,17?-diol.</description><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; STEROIDS</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130726&DB=EPODOC&CC=NZ&NR=596824A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130726&DB=EPODOC&CC=NZ&NR=596824A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIENAU, PHILIP</creatorcontrib><creatorcontrib>BOHLMANN, ROLF</creatorcontrib><creatorcontrib>HUBNER, JAN</creatorcontrib><creatorcontrib>DENNER, KARSTEN</creatorcontrib><creatorcontrib>KUNZER, HERMANN</creatorcontrib><creatorcontrib>KOHR, SILKE</creatorcontrib><creatorcontrib>WINTERMANTEL, TIM</creatorcontrib><creatorcontrib>HEINRICH, NIKOLAUS</creatorcontrib><creatorcontrib>HOFFMANN, JENS</creatorcontrib><creatorcontrib>KETTSCHAU, GEORG</creatorcontrib><creatorcontrib>LANG, DIETER</creatorcontrib><creatorcontrib>GERISCH, MICHAEL</creatorcontrib><creatorcontrib>SANDER, MICHAEL</creatorcontrib><title>17beta-ALKYL-17alpha-OXY-ESTRATRIENES</title><description>Disclosed herein are oestratrienes of general formula (I), wherein the variables are defined in the specification, and the use thereof in in the treatment of oestrogen-dependent disorders. Exemplary compounds include: 11?-fluoro-17?-methyl-7?-[5-[(2R)-2-(6,6,7,7,7-pentafluoroheptyl)-1-pyrrolidinyl]pentyl]oestra-1,3,5(10)-triene-3,17?-diol; and 11?-fluoro-17?-methyl-7?-[5-[methyl(8,8,9,9,9-pentafluorononyl)amino]pentyl]oestra- 1,3,5(10)-triene-3,17?-diol.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>STEROIDS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFA1NE9KLUnUdfTxjvTRNTRPzCnISNT1j4jUdQ0OCXIMCfJ09XMN5mFgTUvMKU7lhdLcDHJuriHOHrqpBfnxqcUFicmpeakl8X5RppZmFkYmjsYEFQAARcYjVA</recordid><startdate>20130726</startdate><enddate>20130726</enddate><creator>LIENAU, PHILIP</creator><creator>BOHLMANN, ROLF</creator><creator>HUBNER, JAN</creator><creator>DENNER, KARSTEN</creator><creator>KUNZER, HERMANN</creator><creator>KOHR, SILKE</creator><creator>WINTERMANTEL, TIM</creator><creator>HEINRICH, NIKOLAUS</creator><creator>HOFFMANN, JENS</creator><creator>KETTSCHAU, GEORG</creator><creator>LANG, DIETER</creator><creator>GERISCH, MICHAEL</creator><creator>SANDER, MICHAEL</creator><scope>EVB</scope></search><sort><creationdate>20130726</creationdate><title>17beta-ALKYL-17alpha-OXY-ESTRATRIENES</title><author>LIENAU, PHILIP ; BOHLMANN, ROLF ; HUBNER, JAN ; DENNER, KARSTEN ; KUNZER, HERMANN ; KOHR, SILKE ; WINTERMANTEL, TIM ; HEINRICH, NIKOLAUS ; HOFFMANN, JENS ; KETTSCHAU, GEORG ; LANG, DIETER ; GERISCH, MICHAEL ; SANDER, MICHAEL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NZ596824A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2013</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>STEROIDS</topic><toplevel>online_resources</toplevel><creatorcontrib>LIENAU, PHILIP</creatorcontrib><creatorcontrib>BOHLMANN, ROLF</creatorcontrib><creatorcontrib>HUBNER, JAN</creatorcontrib><creatorcontrib>DENNER, KARSTEN</creatorcontrib><creatorcontrib>KUNZER, HERMANN</creatorcontrib><creatorcontrib>KOHR, SILKE</creatorcontrib><creatorcontrib>WINTERMANTEL, TIM</creatorcontrib><creatorcontrib>HEINRICH, NIKOLAUS</creatorcontrib><creatorcontrib>HOFFMANN, JENS</creatorcontrib><creatorcontrib>KETTSCHAU, GEORG</creatorcontrib><creatorcontrib>LANG, DIETER</creatorcontrib><creatorcontrib>GERISCH, MICHAEL</creatorcontrib><creatorcontrib>SANDER, MICHAEL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIENAU, PHILIP</au><au>BOHLMANN, ROLF</au><au>HUBNER, JAN</au><au>DENNER, KARSTEN</au><au>KUNZER, HERMANN</au><au>KOHR, SILKE</au><au>WINTERMANTEL, TIM</au><au>HEINRICH, NIKOLAUS</au><au>HOFFMANN, JENS</au><au>KETTSCHAU, GEORG</au><au>LANG, DIETER</au><au>GERISCH, MICHAEL</au><au>SANDER, MICHAEL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>17beta-ALKYL-17alpha-OXY-ESTRATRIENES</title><date>2013-07-26</date><risdate>2013</risdate><abstract>Disclosed herein are oestratrienes of general formula (I), wherein the variables are defined in the specification, and the use thereof in in the treatment of oestrogen-dependent disorders. Exemplary compounds include: 11?-fluoro-17?-methyl-7?-[5-[(2R)-2-(6,6,7,7,7-pentafluoroheptyl)-1-pyrrolidinyl]pentyl]oestra-1,3,5(10)-triene-3,17?-diol; and 11?-fluoro-17?-methyl-7?-[5-[methyl(8,8,9,9,9-pentafluorononyl)amino]pentyl]oestra- 1,3,5(10)-triene-3,17?-diol.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES STEROIDS |
| title | 17beta-ALKYL-17alpha-OXY-ESTRATRIENES |
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