17beta-ALKYL-17alpha-OXY-ESTRATRIENES

Disclosed herein are oestratrienes of general formula (I), wherein the variables are defined in the specification, and the use thereof in in the treatment of oestrogen-dependent disorders. Exemplary compounds include: 11?-fluoro-17?-methyl-7?-[5-[(2R)-2-(6,6,7,7,7-pentafluoroheptyl)-1-pyrrolidinyl]p...

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Hauptverfasser:	LIENAU, PHILIP, BOHLMANN, ROLF, HUBNER, JAN, DENNER, KARSTEN, KUNZER, HERMANN, KOHR, SILKE, WINTERMANTEL, TIM, HEINRICH, NIKOLAUS, HOFFMANN, JENS, KETTSCHAU, GEORG, LANG, DIETER, GERISCH, MICHAEL, SANDER, MICHAEL
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES STEROIDS
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Beschreibung
Zusammenfassung:	Disclosed herein are oestratrienes of general formula (I), wherein the variables are defined in the specification, and the use thereof in in the treatment of oestrogen-dependent disorders. Exemplary compounds include: 11?-fluoro-17?-methyl-7?-[5-[(2R)-2-(6,6,7,7,7-pentafluoroheptyl)-1-pyrrolidinyl]pentyl]oestra-1,3,5(10)-triene-3,17?-diol; and 11?-fluoro-17?-methyl-7?-[5-[methyl(8,8,9,9,9-pentafluorononyl)amino]pentyl]oestra- 1,3,5(10)-triene-3,17?-diol.