Prodrug forms of kinase inhibitors and their use in therapy
595206 Disclosed herein are prodrug compounds comprising a kinase inhibitor and a reductively-activated fragmenting aromatic nitroheterocycle or aromatic nitrocarbocycle trigger, where the compound carries a positive charge. In preferred embodiments, the trigger has the structure of Formula IIId whe...
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| creator | HAY MICHAEL PATRICK LEE HO HUAT ANDERSON ROBERT FORBES WILSON WILLIAM ROBERT ASHOORZADEH AMIR LU GUO-LIANG PATTERSON ADAM VORN SMAILL JEFFREY BRUCE DENNY WILLIAM ALEXANDER |
| description | 595206 Disclosed herein are prodrug compounds comprising a kinase inhibitor and a reductively-activated fragmenting aromatic nitroheterocycle or aromatic nitrocarbocycle trigger, where the compound carries a positive charge. In preferred embodiments, the trigger has the structure of Formula IIId wherein * is a point of attachment, R8 is selected from H and C1-C3 alkyl, and R9 is selected from H and C1-C6 alkyl. The disclosed compounds are useful in treating proliferative diseases such as cancer. |
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In preferred embodiments, the trigger has the structure of Formula IIId wherein * is a point of attachment, R8 is selected from H and C1-C3 alkyl, and R9 is selected from H and C1-C6 alkyl. The disclosed compounds are useful in treating proliferative diseases such as cancer.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140228&DB=EPODOC&CC=NZ&NR=595206A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140228&DB=EPODOC&CC=NZ&NR=595206A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HAY MICHAEL PATRICK</creatorcontrib><creatorcontrib>LEE HO HUAT</creatorcontrib><creatorcontrib>ANDERSON ROBERT FORBES</creatorcontrib><creatorcontrib>WILSON WILLIAM ROBERT</creatorcontrib><creatorcontrib>ASHOORZADEH AMIR</creatorcontrib><creatorcontrib>LU GUO-LIANG</creatorcontrib><creatorcontrib>PATTERSON ADAM VORN</creatorcontrib><creatorcontrib>SMAILL JEFFREY BRUCE</creatorcontrib><creatorcontrib>DENNY WILLIAM ALEXANDER</creatorcontrib><title>Prodrug forms of kinase inhibitors and their use in therapy</title><description>595206 Disclosed herein are prodrug compounds comprising a kinase inhibitor and a reductively-activated fragmenting aromatic nitroheterocycle or aromatic nitrocarbocycle trigger, where the compound carries a positive charge. In preferred embodiments, the trigger has the structure of Formula IIId wherein * is a point of attachment, R8 is selected from H and C1-C3 alkyl, and R9 is selected from H and C1-C6 alkyl. The disclosed compounds are useful in treating proliferative diseases such as cancer.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAOKMpPKSpNV0jLL8otVshPU8jOzEssTlXIzMvITMosyS8qVkjMS1EoyUjNLFIoBUuAOEWJBZU8DKxpiTnFqbxQmptBzs01xNlDN7UgPz61uCAxOTUvtSTeL8rU0tTIwMzRmKACAJbLLkU</recordid><startdate>20140228</startdate><enddate>20140228</enddate><creator>HAY MICHAEL PATRICK</creator><creator>LEE HO HUAT</creator><creator>ANDERSON ROBERT FORBES</creator><creator>WILSON WILLIAM ROBERT</creator><creator>ASHOORZADEH AMIR</creator><creator>LU GUO-LIANG</creator><creator>PATTERSON ADAM VORN</creator><creator>SMAILL JEFFREY BRUCE</creator><creator>DENNY WILLIAM ALEXANDER</creator><scope>EVB</scope></search><sort><creationdate>20140228</creationdate><title>Prodrug forms of kinase inhibitors and their use in therapy</title><author>HAY MICHAEL PATRICK ; LEE HO HUAT ; ANDERSON ROBERT FORBES ; WILSON WILLIAM ROBERT ; ASHOORZADEH AMIR ; LU GUO-LIANG ; PATTERSON ADAM VORN ; SMAILL JEFFREY BRUCE ; DENNY WILLIAM ALEXANDER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NZ595206A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2014</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HAY MICHAEL PATRICK</creatorcontrib><creatorcontrib>LEE HO HUAT</creatorcontrib><creatorcontrib>ANDERSON ROBERT FORBES</creatorcontrib><creatorcontrib>WILSON WILLIAM ROBERT</creatorcontrib><creatorcontrib>ASHOORZADEH AMIR</creatorcontrib><creatorcontrib>LU GUO-LIANG</creatorcontrib><creatorcontrib>PATTERSON ADAM VORN</creatorcontrib><creatorcontrib>SMAILL JEFFREY BRUCE</creatorcontrib><creatorcontrib>DENNY WILLIAM ALEXANDER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HAY MICHAEL PATRICK</au><au>LEE HO HUAT</au><au>ANDERSON ROBERT FORBES</au><au>WILSON WILLIAM ROBERT</au><au>ASHOORZADEH AMIR</au><au>LU GUO-LIANG</au><au>PATTERSON ADAM VORN</au><au>SMAILL JEFFREY BRUCE</au><au>DENNY WILLIAM ALEXANDER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Prodrug forms of kinase inhibitors and their use in therapy</title><date>2014-02-28</date><risdate>2014</risdate><abstract>595206 Disclosed herein are prodrug compounds comprising a kinase inhibitor and a reductively-activated fragmenting aromatic nitroheterocycle or aromatic nitrocarbocycle trigger, where the compound carries a positive charge. In preferred embodiments, the trigger has the structure of Formula IIId wherein * is a point of attachment, R8 is selected from H and C1-C3 alkyl, and R9 is selected from H and C1-C6 alkyl. The disclosed compounds are useful in treating proliferative diseases such as cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Prodrug forms of kinase inhibitors and their use in therapy |
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