QUINOXALINE DERIVATIVES AND THEIR USE FOR TREATING BENIGN AND MALIGNANT TUMOUR DISORDERS

QUINOXALINE DERIVATIVES AND THEIR USE FOR TREATING BENIGN AND MALIGNANT TUMOUR DISORDERS

595064 Disclosed herein is a quinoxaline derivative of formula I, wherein the variables are defined in the specification, a pharmaceutical composition and medicament comprising said compound, and the use of said compound in the treatment of tumour disorders such as active compound-resistant tumour d...

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Bibliographische Detailangaben
Hauptverfasser: SEIPELT, IRENE, GUNTHER, ECKHARD, SCHUSTER, TILMANN, CZECH, MICHAEL, CLAUS, ECKHARD, POLYMEROPOULOS, EMMANUEL, GERLACH, MATTHIAS
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:595064 Disclosed herein is a quinoxaline derivative of formula I, wherein the variables are defined in the specification, a pharmaceutical composition and medicament comprising said compound, and the use of said compound in the treatment of tumour disorders such as active compound-resistant tumour disorders and metastasic carinomas. Embodiments of the compound include the following: 1-[7-(4-hydroxy-3-methoxyphenyl)quinoxalin-2-yl]-3-[1-(2,2,2-trifluoroacetyl)piperidin-4-yl]urea, 1-cyclopropyl-3-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]thiourea, and 1-[7-(3,5-dichloro-4-hydroxy-phenyl)-quinoxalin-2-yl]-3-heptyl-urea.