DRIED RASAGILINE BASE HAVING A WATER CONTENT LESS THAN 0.5 % BY WEIGHT

DRIED RASAGILINE BASE HAVING A WATER CONTENT LESS THAN 0.5 % BY WEIGHT

589547 Disclosed is solid rasagiline (also known as R(+)-N-propargyl-1-aminoindan / (R)-N-(prop-2-ynyl)-2,3-dihydro-1H-inden-1-amine) containing water at an amount of less than 0.5% by weight; wherein said rasagiline may be obtainable by exposing solid rasagiline to a temperature of between 23 DEGRE...

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Hauptverfasser: FRENKEL, ANTON, BEN-DAVID, RONEN
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator FRENKEL, ANTON
BEN-DAVID, RONEN
description 589547 Disclosed is solid rasagiline (also known as R(+)-N-propargyl-1-aminoindan / (R)-N-(prop-2-ynyl)-2,3-dihydro-1H-inden-1-amine) containing water at an amount of less than 0.5% by weight; wherein said rasagiline may be obtainable by exposing solid rasagiline to a temperature of between 23 DEGREE C and 35 DEGREE C and a pressure of between 4-47 mbar for an amount of time suitable to dry the solid rasagiline. Further disclosed is a pharmaceutical composition comprising crystalline rasagiline as defined above and a pharmaceutically acceptable carrier, wherein said crystalline rasagiline has an X-ray diffraction pattern having peaks at 8.5, 12.6, 16.1 and 16.9.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title DRIED RASAGILINE BASE HAVING A WATER CONTENT LESS THAN 0.5 % BY WEIGHT
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