PYRIMIDINE DERIVATIVES USEFUL AS RAF KINASE INHIBITORS

Disclosed is a compound of formula I e.g. 2-(1-(6-acetamidopyrimidine-4-carboxamido)ethyl)-N-( 5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-1H-carboxamide or a pharmaceutically acceptable salt thereof, wherein: disorder is selected from a proliferative disorder, a cardiac disorder, a neurodeg...

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Bibliographische Detailangaben
Hauptverfasser:	COSSROW, JENNIFER, TANAKA, HIROKO, VESSELS, JEFFREY, JONES, JOHN HOWARD, LITTKE, ADAM, RAIMUNDO, BRIAN, PENG, HAIRUO, KUMARAVEL, GNANASAMBANDAM, XIN, ZHILI, GUAN, BING, POWELL, NOEL, CHEN, WEIRONG, WYNN, THOMAS, LANE, BENJAMIN, FRANKLIN, LIOYD, LUGOVSKOY, ALEXEY
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed is a compound of formula I e.g. 2-(1-(6-acetamidopyrimidine-4-carboxamido)ethyl)-N-( 5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-1H-carboxamide or a pharmaceutically acceptable salt thereof, wherein: disorder is selected from a proliferative disorder, a cardiac disorder, a neurodegenerative disorder, an autoimmune disorder, a condition associated with organ transplant, an inflammatory disorder, an immunologically-mediated disorder, a viral disease, or a bone disorder.