Changing Th1/Th2 balance in split influenza vaccines with adjuvants
Disclosed is an immunogenic composition comprising a split influenza virus antigen when prepared from a virus grown in cell culture, and a Th1 adjuvant in the form of an oil-in-water emulsion comprising oil droplets having a submicron diameter, wherein said emulsion comprises squalene, and wherein s...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | Disclosed is an immunogenic composition comprising a split influenza virus antigen when prepared from a virus grown in cell culture, and a Th1 adjuvant in the form of an oil-in-water emulsion comprising oil droplets having a submicron diameter, wherein said emulsion comprises squalene, and wherein said composition does not comprise any egg proteins. Also disclosed is the use of the composition in the manufacture of a medicament for raising an immune response against influenza virus in a subject. Further disclosed is a method for preparing the immunogenic composition said method comprising combining a split influenza virus antigen prepared from a virus grown in cell culture that does not comprise any egg proteins and a Th1 adjuvant in the form of an oil-in-water emulsion comprising oil droplets having a submicron diameter, wherein said emulsion comprises squalene |
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