Method for isolating etidronate disodium

Method for isolating etidronate disodium

A method for isolating etidronate disodium is disclosed, wherein (a) a liquid-liquid dispersion consisting of an aqueous-organic phase and an aqueous phase containing the etidronate disodium salt is set to a temperature of between 0 °C and 30 °C and is intensively mixed; (b) a coarse-grained fractio...

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Hauptverfasser: RATHE, HARALD, SCHMIDT, BARBARA, GRAWE, DETLEF
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ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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creator RATHE, HARALD
SCHMIDT, BARBARA
GRAWE, DETLEF
description A method for isolating etidronate disodium is disclosed, wherein (a) a liquid-liquid dispersion consisting of an aqueous-organic phase and an aqueous phase containing the etidronate disodium salt is set to a temperature of between 0 °C and 30 °C and is intensively mixed; (b) a coarse-grained fraction is subsequently precipitated out of the liquid-liquid dispersion and; (c) in a second, delayed step, a fine-grained fraction is precipitated out of the organic phase. The invention also relates to a novel solid form of etidronate disodium that can be obtained using this method. Etidronate disodium produced by this method has a particle size in the region of 0.2 to 1.0 mm, good flowability and a high bulk density, and is coupled with properties that can be pharmaceutically exploited.
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The invention also relates to a novel solid form of etidronate disodium that can be obtained using this method. 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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title Method for isolating etidronate disodium
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