Controlled release drug dosage core comprising a drug-containing composition and a water-swellable composition

Controlled release drug dosage core comprising a drug-containing composition and a water-swellable composition

A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating aroun...

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Bibliographische Detailangaben
Hauptverfasser: CURATOLO, WILLIAM JOHN, FRIESEN, DWAYNE THOMAS, BEYERINCK, RONALD ARTHUR, CHIDLAW, MARK BRIAN, APPEL, LEAH ELIZABETH, SMITH, KELLY LINCOLN, THOMBRE, AVINASH GOVIND
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific drug release profiles are disclosed.