Using PAI-2 and t-PA as diagnostic markers of periodontal disease

A method of diagnosing periodontal disease, comprises: a) determining the level of a protein in individual gingival crevicular fluid (GCF) samples, each sample being obtained from one of various sites of a patient, wherein the protein is selected from the group consisting of: i) tissue-type plasmino...

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Bibliographische Detailangaben
Hauptverfasser:	XIAO, YIN, BUNN, CLIVE L, BARTOLD, PETER M
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A method of diagnosing periodontal disease, comprises: a) determining the level of a protein in individual gingival crevicular fluid (GCF) samples, each sample being obtained from one of various sites of a patient, wherein the protein is selected from the group consisting of: i) tissue-type plasminogen activator (t-PA) and ii) plasminogen activator inhibitor-2 (PAI-2) and b) obtaining the mean level of the protein in the GCF and using the mean level to diagnose periodontal disease whereby periodontitis is distinguished from gingivitis. The GCF is collected locally from two or more sites of the patient selected from the mesial sites, the buccal and labial sites on the lower teeth. The level of the compound is determined using an enzyme-linked immunosorbent assay. Step b) can further include comparing the mean level of the protein in the GCF from the patient with a predetermined mean level of the protein in the GCF from a healthy individual. A statistically significant increase of the mean level of the protein in the GCF indicates the presence of periodontal disease.