1-(7-CHLOROQUINOLIN-4-YL)-5-(2,6-DIHYDROXYPHENYL)-PYRAZOLE-3- CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS

1-(7-CHLOROQUINOLIN-4-YL)-5-(2,6-DIHYDROXYPHENYL)-PYRAZOLE-3- CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS

N-(Carboxyalkyl)-1-(7-chloro-4-quinolyl)-5-phenyl pyrazole-3-carboxamide N-oxide derivs. of formula (I) and their salts are new. T = H, 1-4C alkyl, 3-8C cycloalkyl, (3-8C) cycloalkylmethyl or methoxyethyl; -NH-AA(OH) = amino acid residue of formula -NH-CXX'-COOH; X = H, 1-5C alkyl or non-aromat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BOIGEGRAIN, ROBERT, JEANJEAN, FRANCIS, GULLY, DANIELE, PRADINES, ANTOINE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:N-(Carboxyalkyl)-1-(7-chloro-4-quinolyl)-5-phenyl pyrazole-3-carboxamide N-oxide derivs. of formula (I) and their salts are new. T = H, 1-4C alkyl, 3-8C cycloalkyl, (3-8C) cycloalkylmethyl or methoxyethyl; -NH-AA(OH) = amino acid residue of formula -NH-CXX'-COOH; X = H, 1-5C alkyl or non-aromatic 3-15C carbocyclic gp.; X' = H; or CXX' = non-aromatic 3-15C carbocyclic gp. Also claimed are intermediates of formulae (II) (see 'Preparation')and (IV) (see 'Starting Materials'), where T = 3-8C cycloalkyl, (3-8C) cycloalkylmethyl or methoxyethyl.