MALONATO PLATINUM COMPOSITION; STABLE INJECTABLE PHARMACEUTICAL COMPOSITIONS PREPARED USING 1,1-CYCLOBUTANEDICARBOXYLIC ACID AS STABILISER

MALONATO PLATINUM COMPOSITION; STABLE INJECTABLE PHARMACEUTICAL COMPOSITIONS PREPARED USING 1,1-CYCLOBUTANEDICARBOXYLIC ACID AS STABILISER

Solutions of carboplatin and other malonato platinum(II) antitumor agents are prepared containing stabilizing amounts of 1,1-cyclobutanedicarboxylic acid or salt at pH 4-8. The stabilizers inhibit unacceptable discoloration and precipitation. The solutions may also be stabilized by purging the carri...

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Hauptverfasser: PHUSANTI, LAWAN, PERRONE, ROBERT K, KAPLAN, MURRAY A, STENBERG, SCOTT R, BOGARDUS, JOSEPH B, AGHARKAR, SHEERAM
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator PHUSANTI, LAWAN
PERRONE, ROBERT K
KAPLAN, MURRAY A
STENBERG, SCOTT R
BOGARDUS, JOSEPH B
AGHARKAR, SHEERAM
description Solutions of carboplatin and other malonato platinum(II) antitumor agents are prepared containing stabilizing amounts of 1,1-cyclobutanedicarboxylic acid or salt at pH 4-8. The stabilizers inhibit unacceptable discoloration and precipitation. The solutions may also be stabilized by purging the carrier with air or oxygen and, optionally, blanketing the headspace with air or oxygen.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title MALONATO PLATINUM COMPOSITION; STABLE INJECTABLE PHARMACEUTICAL COMPOSITIONS PREPARED USING 1,1-CYCLOBUTANEDICARBOXYLIC ACID AS STABILISER
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