AN ANTIGEN OF PLASMODIUM FALCIPARUM, ANTIBODIES TO IT, ANTIGENIC FRAGMENTS AND PHARMACEUTICAL COMPOSITIONS
A small molecular weight antigen of the asexual blood stages of Plasmodium falciparum which is characterized by: (i) having an apparent molecular weight in the range of approximately 15 kD to 19 kD; (ii) not showing significant glycosylation by galactose or glucosamine labelling, but being acylated...
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| creator | SAUL, ALLAN JAMES KARA, URSULA ANNA KATE STENZEL, DEBORAH JOAN GEYSEN, HENDRIK MARIO BUSHELL, GILLIAN ROBIN |
| description | A small molecular weight antigen of the asexual blood stages of Plasmodium falciparum which is characterized by: (i) having an apparent molecular weight in the range of approximately 15 kD to 19 kD; (ii) not showing significant glycosylation by galactose or glucosamine labelling, but being acylated by myristic acid; (iii) being associated with the parasitophorous vacuole membrane and with inclusions and vesicles residing within the cytoplasm of the erythrocyte host cell; and (iv) being recognised by monoclonal antibodies against the asexual blood stages of P. falciparum which inhibit parasite growth in vitro; or an antigenic fragment thereof. A monoclonal antibody specific for this antigen, and a hybrid cell line which produces this antibody is also disclosed. |
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A monoclonal antibody specific for this antigen, and a hybrid cell line which produces this antibody is also disclosed.</description><edition>4</edition><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES USING MICROORGANISMS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>1991</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19910426&DB=EPODOC&CC=NZ&NR=221115A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19910426&DB=EPODOC&CC=NZ&NR=221115A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SAUL, ALLAN JAMES</creatorcontrib><creatorcontrib>KARA, URSULA ANNA KATE</creatorcontrib><creatorcontrib>STENZEL, DEBORAH JOAN</creatorcontrib><creatorcontrib>GEYSEN, HENDRIK MARIO</creatorcontrib><creatorcontrib>BUSHELL, GILLIAN ROBIN</creatorcontrib><title>AN ANTIGEN OF PLASMODIUM FALCIPARUM, ANTIBODIES TO IT, ANTIGENIC FRAGMENTS AND PHARMACEUTICAL COMPOSITIONS</title><description>A small molecular weight antigen of the asexual blood stages of Plasmodium falciparum which is characterized by: (i) having an apparent molecular weight in the range of approximately 15 kD to 19 kD; (ii) not showing significant glycosylation by galactose or glucosamine labelling, but being acylated by myristic acid; (iii) being associated with the parasitophorous vacuole membrane and with inclusions and vesicles residing within the cytoplasm of the erythrocyte host cell; and (iv) being recognised by monoclonal antibodies against the asexual blood stages of P. falciparum which inhibit parasite growth in vitro; or an antigenic fragment thereof. A monoclonal antibody specific for this antigen, and a hybrid cell line which produces this antibody is also disclosed.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES USING MICROORGANISMS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1991</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFi0sKwjAUALNxIeoV5B2gLlrxAM80aR80H5KXTTelSFyIaKHeH4vo2tXAMLMWN7SAlqlRFpwG32E0rqZkQGMnyWNIpvgU50WrCOyAuPg9JEEHbIyyHBdXg28xGJQqMUnsQDrjXSQmZ-NWrK7jfc67LzdirxXL9pCn55DnabzkR34Ntq-qsixPePwbvAExSDTq</recordid><startdate>19910426</startdate><enddate>19910426</enddate><creator>SAUL, ALLAN JAMES</creator><creator>KARA, URSULA ANNA KATE</creator><creator>STENZEL, DEBORAH JOAN</creator><creator>GEYSEN, HENDRIK MARIO</creator><creator>BUSHELL, GILLIAN ROBIN</creator><scope>EVB</scope></search><sort><creationdate>19910426</creationdate><title>AN ANTIGEN OF PLASMODIUM FALCIPARUM, ANTIBODIES TO IT, ANTIGENIC FRAGMENTS AND PHARMACEUTICAL COMPOSITIONS</title><author>SAUL, ALLAN JAMES ; KARA, URSULA ANNA KATE ; STENZEL, DEBORAH JOAN ; GEYSEN, HENDRIK MARIO ; BUSHELL, GILLIAN ROBIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NZ221115A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1991</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES USING MICROORGANISMS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>SAUL, ALLAN JAMES</creatorcontrib><creatorcontrib>KARA, URSULA ANNA KATE</creatorcontrib><creatorcontrib>STENZEL, DEBORAH JOAN</creatorcontrib><creatorcontrib>GEYSEN, HENDRIK MARIO</creatorcontrib><creatorcontrib>BUSHELL, GILLIAN ROBIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SAUL, ALLAN JAMES</au><au>KARA, URSULA ANNA KATE</au><au>STENZEL, DEBORAH JOAN</au><au>GEYSEN, HENDRIK MARIO</au><au>BUSHELL, GILLIAN ROBIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>AN ANTIGEN OF PLASMODIUM FALCIPARUM, ANTIBODIES TO IT, ANTIGENIC FRAGMENTS AND PHARMACEUTICAL COMPOSITIONS</title><date>1991-04-26</date><risdate>1991</risdate><abstract>A small molecular weight antigen of the asexual blood stages of Plasmodium falciparum which is characterized by: (i) having an apparent molecular weight in the range of approximately 15 kD to 19 kD; (ii) not showing significant glycosylation by galactose or glucosamine labelling, but being acylated by myristic acid; (iii) being associated with the parasitophorous vacuole membrane and with inclusions and vesicles residing within the cytoplasm of the erythrocyte host cell; and (iv) being recognised by monoclonal antibodies against the asexual blood stages of P. falciparum which inhibit parasite growth in vitro; or an antigenic fragment thereof. A monoclonal antibody specific for this antigen, and a hybrid cell line which produces this antibody is also disclosed.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | AN ANTIGEN OF PLASMODIUM FALCIPARUM, ANTIBODIES TO IT, ANTIGENIC FRAGMENTS AND PHARMACEUTICAL COMPOSITIONS |
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