Endoteliareseptorantagonister
Det blir fremskaffet nye forbindelser representert ved den generelle formel I: hvor R1 er rettledet eller forgrenet lavere alkyl, en cykloalkyl lavere alkyl, en aryllavere alkyl, en cykloalkyl, en aryl, en arylcykloalkyl, lavere alkokey, en aryloksy, eller en heteroaryl; R2 er hydrogen, en rett elle...
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| creator | PITTERNA, THOMAS OKADA, TOSHIKAZU FRUH, THOMAS MURATA, TOSHIKI SVENSSON, LENE D SAIKA, HIDEYUKI URADE, YOSHIHIRO YAMAMURA, TAKAKI |
| description | Det blir fremskaffet nye forbindelser representert ved den generelle formel I: hvor R1 er rettledet eller forgrenet lavere alkyl, en cykloalkyl lavere alkyl, en aryllavere alkyl, en cykloalkyl, en aryl, en arylcykloalkyl, lavere alkokey, en aryloksy, eller en heteroaryl; R2 er hydrogen, en rett eller forgrenet lavere alkyl, en cykloalkyl eller en cykloalkyl lavere alkyl; R3 og R3, er hver Ilke eller forskjellige og er hver hydrogen, en rettkjedet eller forgrenet lavere alkyl, en cykloalkyl, en aryl lavere alkyl, en aryl, eller en heteroaryl; eller R3 og R3> danner sammen en rlngstruktur; R3» er hydrogen, lavere alkyl eller en aryl; eller R2 og R3« danner sammen en lavere alkylengruppe -(CH2)n- hvor n er et helt tall på l, 2,4 eller 3; eller R2 og R3« danner sammen en gruppe representert ved formelen: -(CHo^-Ar- eller -Ar-(CH2)p, hvor p er null eller et helt tall på l eller 2, og Ar er en arylen eller heteroarylen; C(-X) er C(-0), C(-S), C(-NH)-, C(-N-lavere alkyl); C-NH-OH, eller CH2; Y er en dlrekteblndlng, -NH-, en lavere alkyl-N |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_NO961725LL</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>NO961725LL</sourcerecordid><originalsourceid>FETCH-epo_espacenet_NO961725LL3</originalsourceid><addsrcrecordid>eNrjZJB1zUvJL0nNyUwsSi1OLSjJL0rMK0lMz8_LLC5JLeJhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfF-_pZmhuZGpj4-xoRVAACsVSS6</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Endoteliareseptorantagonister</title><source>esp@cenet</source><creator>PITTERNA, THOMAS ; OKADA, TOSHIKAZU ; FRUH, THOMAS ; MURATA, TOSHIKI ; SVENSSON, LENE D ; SAIKA, HIDEYUKI ; URADE, YOSHIHIRO ; YAMAMURA, TAKAKI</creator><creatorcontrib>PITTERNA, THOMAS ; OKADA, TOSHIKAZU ; FRUH, THOMAS ; MURATA, TOSHIKI ; SVENSSON, LENE D ; SAIKA, HIDEYUKI ; URADE, YOSHIHIRO ; YAMAMURA, TAKAKI</creatorcontrib><description>Det blir fremskaffet nye forbindelser representert ved den generelle formel I: hvor R1 er rettledet eller forgrenet lavere alkyl, en cykloalkyl lavere alkyl, en aryllavere alkyl, en cykloalkyl, en aryl, en arylcykloalkyl, lavere alkokey, en aryloksy, eller en heteroaryl; R2 er hydrogen, en rett eller forgrenet lavere alkyl, en cykloalkyl eller en cykloalkyl lavere alkyl; R3 og R3, er hver Ilke eller forskjellige og er hver hydrogen, en rettkjedet eller forgrenet lavere alkyl, en cykloalkyl, en aryl lavere alkyl, en aryl, eller en heteroaryl; eller R3 og R3> danner sammen en rlngstruktur; R3» er hydrogen, lavere alkyl eller en aryl; eller R2 og R3« danner sammen en lavere alkylengruppe -(CH2)n- hvor n er et helt tall på l, 2,4 eller 3; eller R2 og R3« danner sammen en gruppe representert ved formelen: -(CHo^-Ar- eller -Ar-(CH2)p, hvor p er null eller et helt tall på l eller 2, og Ar er en arylen eller heteroarylen; C(-X) er C(-0), C(-S), C(-NH)-, C(-N-lavere alkyl); C-NH-OH, eller CH2; Y er en dlrekteblndlng, -NH-, en lavere alkyl-N<^ , et oksygenatom, eller metylen; eller C(-X) er CHOH og Y er en direkte binding eller metylen; 84 er -(CH2)s-Ar' hvor s er null eller et helt tall på l, 2 eller 3; og Ar' er aryl, eller en heteroaryl; og RS er karboksy, substituert eller ikke- substltuert karboksamld, PO(OH)2t tetrazol, C^OH, CN, eller hydrogen; og salter derav.
PCT No. PCT/EP94/03418 Sec. 371 Date Apr. 30, 1996 Sec. 102(e) Date Apr. 30, 1996 PCT Filed Oct. 17, 1994 PCT Pub. No. WO95/12611 PCT Pub. Date May 11, 1995The present invention provides novel compounds represented by the general formula I: (I) wherein R1 is a straight or branched lower alkyl, a cycloalkyl-lower alkyl, an aryl-lower alkyl, a cycloalkyl, an aryl an aryl-cycloalkyl, lower alkoxy, an aryloxy, or a heteroaryl; R2 is hydrogen, a straight or branched lower alkyl, a cycloalkyl, or a cycloalkyl-lower alkyl; R3 and R3' are each the same or different and each is hydrogen atom, a straight or branched lower alkyl, a cycloalkyl, an aryl-lower alkyl, an aryl, or a heteroaryl; or R3 and R3' together form a ring structure; R3'' is hydrogen, lower alkyl or an aryl; or R2 and R3'' together form a lower alkylene group -(CH2)n- wherein n is an integer of 1, 2 or 3; or R2 and R3'' together form a group represented by the formula: -(CH2)p-Ar- or -Ar-(CH2)p-, respectively, wherein p is zero or an integer of 1 or 2, and Ar is an arylene or heteroarylene; C(=X) is C(=O), C(=S), C(=NH), C(=N-lower alkyl); C=NH-OH, or CH2; Y is a direct bond, -NH-, a lower alkyl-N<, an oxygen atom, or methylene; or C(=X) is CHOH and Y is a direct bond or methylene; R4 is -(CH2)s-Ar' wherein s is zero or an integer of 1, 2 or 3; and Ar' is an aryl, or a heteroaryl; and R5 is carboxy, substituted or unsubstituted carboxamide, PO(OH)2, tetrazole, CH2OH, CN, or hydrogen; and salts thereof.</description><edition>6</edition><language>nor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960429&DB=EPODOC&CC=NO&NR=961725L$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960429&DB=EPODOC&CC=NO&NR=961725L$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PITTERNA, THOMAS</creatorcontrib><creatorcontrib>OKADA, TOSHIKAZU</creatorcontrib><creatorcontrib>FRUH, THOMAS</creatorcontrib><creatorcontrib>MURATA, TOSHIKI</creatorcontrib><creatorcontrib>SVENSSON, LENE D</creatorcontrib><creatorcontrib>SAIKA, HIDEYUKI</creatorcontrib><creatorcontrib>URADE, YOSHIHIRO</creatorcontrib><creatorcontrib>YAMAMURA, TAKAKI</creatorcontrib><title>Endoteliareseptorantagonister</title><description>Det blir fremskaffet nye forbindelser representert ved den generelle formel I: hvor R1 er rettledet eller forgrenet lavere alkyl, en cykloalkyl lavere alkyl, en aryllavere alkyl, en cykloalkyl, en aryl, en arylcykloalkyl, lavere alkokey, en aryloksy, eller en heteroaryl; R2 er hydrogen, en rett eller forgrenet lavere alkyl, en cykloalkyl eller en cykloalkyl lavere alkyl; R3 og R3, er hver Ilke eller forskjellige og er hver hydrogen, en rettkjedet eller forgrenet lavere alkyl, en cykloalkyl, en aryl lavere alkyl, en aryl, eller en heteroaryl; eller R3 og R3> danner sammen en rlngstruktur; R3» er hydrogen, lavere alkyl eller en aryl; eller R2 og R3« danner sammen en lavere alkylengruppe -(CH2)n- hvor n er et helt tall på l, 2,4 eller 3; eller R2 og R3« danner sammen en gruppe representert ved formelen: -(CHo^-Ar- eller -Ar-(CH2)p, hvor p er null eller et helt tall på l eller 2, og Ar er en arylen eller heteroarylen; C(-X) er C(-0), C(-S), C(-NH)-, C(-N-lavere alkyl); C-NH-OH, eller CH2; Y er en dlrekteblndlng, -NH-, en lavere alkyl-N<^ , et oksygenatom, eller metylen; eller C(-X) er CHOH og Y er en direkte binding eller metylen; 84 er -(CH2)s-Ar' hvor s er null eller et helt tall på l, 2 eller 3; og Ar' er aryl, eller en heteroaryl; og RS er karboksy, substituert eller ikke- substltuert karboksamld, PO(OH)2t tetrazol, C^OH, CN, eller hydrogen; og salter derav.
PCT No. PCT/EP94/03418 Sec. 371 Date Apr. 30, 1996 Sec. 102(e) Date Apr. 30, 1996 PCT Filed Oct. 17, 1994 PCT Pub. No. WO95/12611 PCT Pub. Date May 11, 1995The present invention provides novel compounds represented by the general formula I: (I) wherein R1 is a straight or branched lower alkyl, a cycloalkyl-lower alkyl, an aryl-lower alkyl, a cycloalkyl, an aryl an aryl-cycloalkyl, lower alkoxy, an aryloxy, or a heteroaryl; R2 is hydrogen, a straight or branched lower alkyl, a cycloalkyl, or a cycloalkyl-lower alkyl; R3 and R3' are each the same or different and each is hydrogen atom, a straight or branched lower alkyl, a cycloalkyl, an aryl-lower alkyl, an aryl, or a heteroaryl; or R3 and R3' together form a ring structure; R3'' is hydrogen, lower alkyl or an aryl; or R2 and R3'' together form a lower alkylene group -(CH2)n- wherein n is an integer of 1, 2 or 3; or R2 and R3'' together form a group represented by the formula: -(CH2)p-Ar- or -Ar-(CH2)p-, respectively, wherein p is zero or an integer of 1 or 2, and Ar is an arylene or heteroarylene; C(=X) is C(=O), C(=S), C(=NH), C(=N-lower alkyl); C=NH-OH, or CH2; Y is a direct bond, -NH-, a lower alkyl-N<, an oxygen atom, or methylene; or C(=X) is CHOH and Y is a direct bond or methylene; R4 is -(CH2)s-Ar' wherein s is zero or an integer of 1, 2 or 3; and Ar' is an aryl, or a heteroaryl; and R5 is carboxy, substituted or unsubstituted carboxamide, PO(OH)2, tetrazole, CH2OH, CN, or hydrogen; and salts thereof.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJB1zUvJL0nNyUwsSi1OLSjJL0rMK0lMz8_LLC5JLeJhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfF-_pZmhuZGpj4-xoRVAACsVSS6</recordid><startdate>19960429</startdate><enddate>19960429</enddate><creator>PITTERNA, THOMAS</creator><creator>OKADA, TOSHIKAZU</creator><creator>FRUH, THOMAS</creator><creator>MURATA, TOSHIKI</creator><creator>SVENSSON, LENE D</creator><creator>SAIKA, HIDEYUKI</creator><creator>URADE, YOSHIHIRO</creator><creator>YAMAMURA, TAKAKI</creator><scope>EVB</scope></search><sort><creationdate>19960429</creationdate><title>Endoteliareseptorantagonister</title><author>PITTERNA, THOMAS ; OKADA, TOSHIKAZU ; FRUH, THOMAS ; MURATA, TOSHIKI ; SVENSSON, LENE D ; SAIKA, HIDEYUKI ; URADE, YOSHIHIRO ; YAMAMURA, TAKAKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NO961725LL3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>nor</language><creationdate>1996</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PITTERNA, THOMAS</creatorcontrib><creatorcontrib>OKADA, TOSHIKAZU</creatorcontrib><creatorcontrib>FRUH, THOMAS</creatorcontrib><creatorcontrib>MURATA, TOSHIKI</creatorcontrib><creatorcontrib>SVENSSON, LENE D</creatorcontrib><creatorcontrib>SAIKA, HIDEYUKI</creatorcontrib><creatorcontrib>URADE, YOSHIHIRO</creatorcontrib><creatorcontrib>YAMAMURA, TAKAKI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PITTERNA, THOMAS</au><au>OKADA, TOSHIKAZU</au><au>FRUH, THOMAS</au><au>MURATA, TOSHIKI</au><au>SVENSSON, LENE D</au><au>SAIKA, HIDEYUKI</au><au>URADE, YOSHIHIRO</au><au>YAMAMURA, TAKAKI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Endoteliareseptorantagonister</title><date>1996-04-29</date><risdate>1996</risdate><abstract>Det blir fremskaffet nye forbindelser representert ved den generelle formel I: hvor R1 er rettledet eller forgrenet lavere alkyl, en cykloalkyl lavere alkyl, en aryllavere alkyl, en cykloalkyl, en aryl, en arylcykloalkyl, lavere alkokey, en aryloksy, eller en heteroaryl; R2 er hydrogen, en rett eller forgrenet lavere alkyl, en cykloalkyl eller en cykloalkyl lavere alkyl; R3 og R3, er hver Ilke eller forskjellige og er hver hydrogen, en rettkjedet eller forgrenet lavere alkyl, en cykloalkyl, en aryl lavere alkyl, en aryl, eller en heteroaryl; eller R3 og R3> danner sammen en rlngstruktur; R3» er hydrogen, lavere alkyl eller en aryl; eller R2 og R3« danner sammen en lavere alkylengruppe -(CH2)n- hvor n er et helt tall på l, 2,4 eller 3; eller R2 og R3« danner sammen en gruppe representert ved formelen: -(CHo^-Ar- eller -Ar-(CH2)p, hvor p er null eller et helt tall på l eller 2, og Ar er en arylen eller heteroarylen; C(-X) er C(-0), C(-S), C(-NH)-, C(-N-lavere alkyl); C-NH-OH, eller CH2; Y er en dlrekteblndlng, -NH-, en lavere alkyl-N<^ , et oksygenatom, eller metylen; eller C(-X) er CHOH og Y er en direkte binding eller metylen; 84 er -(CH2)s-Ar' hvor s er null eller et helt tall på l, 2 eller 3; og Ar' er aryl, eller en heteroaryl; og RS er karboksy, substituert eller ikke- substltuert karboksamld, PO(OH)2t tetrazol, C^OH, CN, eller hydrogen; og salter derav.
PCT No. PCT/EP94/03418 Sec. 371 Date Apr. 30, 1996 Sec. 102(e) Date Apr. 30, 1996 PCT Filed Oct. 17, 1994 PCT Pub. No. WO95/12611 PCT Pub. Date May 11, 1995The present invention provides novel compounds represented by the general formula I: (I) wherein R1 is a straight or branched lower alkyl, a cycloalkyl-lower alkyl, an aryl-lower alkyl, a cycloalkyl, an aryl an aryl-cycloalkyl, lower alkoxy, an aryloxy, or a heteroaryl; R2 is hydrogen, a straight or branched lower alkyl, a cycloalkyl, or a cycloalkyl-lower alkyl; R3 and R3' are each the same or different and each is hydrogen atom, a straight or branched lower alkyl, a cycloalkyl, an aryl-lower alkyl, an aryl, or a heteroaryl; or R3 and R3' together form a ring structure; R3'' is hydrogen, lower alkyl or an aryl; or R2 and R3'' together form a lower alkylene group -(CH2)n- wherein n is an integer of 1, 2 or 3; or R2 and R3'' together form a group represented by the formula: -(CH2)p-Ar- or -Ar-(CH2)p-, respectively, wherein p is zero or an integer of 1 or 2, and Ar is an arylene or heteroarylene; C(=X) is C(=O), C(=S), C(=NH), C(=N-lower alkyl); C=NH-OH, or CH2; Y is a direct bond, -NH-, a lower alkyl-N<, an oxygen atom, or methylene; or C(=X) is CHOH and Y is a direct bond or methylene; R4 is -(CH2)s-Ar' wherein s is zero or an integer of 1, 2 or 3; and Ar' is an aryl, or a heteroaryl; and R5 is carboxy, substituted or unsubstituted carboxamide, PO(OH)2, tetrazole, CH2OH, CN, or hydrogen; and salts thereof.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Endoteliareseptorantagonister |
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