Bis-imid polysykliske og heterosykliske kromoforer som er anvendbare som tumoricidale midler
Oppfinnelsen angår bis-imid- derivater av tri- og tetraaminer av formel (I) Y1 (D farmasøytiske preparater inneholdende disse og metoder for anvendelse av disse for å behandle kreft, i særdeles- het faste tumorer, i pattedyr. Anticancer compounds of formula I: (I) and pharmaceutically acceptable sal...
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| creator | PATTEN, ARTHUR DAVID SEITZ, STEVEN PAUL PACOFSKY, GREGORY JAMES KALTENBACH III, ROBERT FRANK ORWAT, MICHAEL JAMES AKAMIKE, EMEKA AMAECHI CHERNEY, ROBERT JOSEPH |
| description | Oppfinnelsen angår bis-imid- derivater av tri- og tetraaminer av formel (I) Y1 (D farmasøytiske preparater inneholdende disse og metoder for anvendelse av disse for å behandle kreft, i særdeles- het faste tumorer, i pattedyr.
Anticancer compounds of formula I: (I) and pharmaceutically acceptable salts thereof, wherein: R1, R2 and R3 are independently selected H, CH3, NH2, NO2, and CN; R9 and R10 are H or alkyl or halo, X1 and Y1 or X2 and Y2, when present, join together to form, independently, a six membered 1N heterocycle substituted with 1-2 R3; or the group: wherein one of W or Z is C=O and the other is C=O, NH, S or O; or when X2 and Y2 are not joined together and when R2 is in the 4-position, then X2 and R2 may join together to form an ethylene bridge; are disclosed. |
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Anticancer compounds of formula I: (I) and pharmaceutically acceptable salts thereof, wherein: R1, R2 and R3 are independently selected H, CH3, NH2, NO2, and CN; R9 and R10 are H or alkyl or halo, X1 and Y1 or X2 and Y2, when present, join together to form, independently, a six membered 1N heterocycle substituted with 1-2 R3; or the group: wherein one of W or Z is C=O and the other is C=O, NH, S or O; or when X2 and Y2 are not joined together and when R2 is in the 4-position, then X2 and R2 may join together to form an ethylene bridge; are disclosed.</description><edition>6</edition><language>nor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960226&DB=EPODOC&CC=NO&NR=955257L$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960226&DB=EPODOC&CC=NO&NR=955257L$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PATTEN, ARTHUR DAVID</creatorcontrib><creatorcontrib>SEITZ, STEVEN PAUL</creatorcontrib><creatorcontrib>PACOFSKY, GREGORY JAMES</creatorcontrib><creatorcontrib>KALTENBACH III, ROBERT FRANK</creatorcontrib><creatorcontrib>ORWAT, MICHAEL JAMES</creatorcontrib><creatorcontrib>AKAMIKE, EMEKA AMAECHI</creatorcontrib><creatorcontrib>CHERNEY, ROBERT JOSEPH</creatorcontrib><title>Bis-imid polysykliske og heterosykliske kromoforer som er anvendbare som tumoricidale midler</title><description>Oppfinnelsen angår bis-imid- derivater av tri- og tetraaminer av formel (I) Y1 (D farmasøytiske preparater inneholdende disse og metoder for anvendelse av disse for å behandle kreft, i særdeles- het faste tumorer, i pattedyr.
Anticancer compounds of formula I: (I) and pharmaceutically acceptable salts thereof, wherein: R1, R2 and R3 are independently selected H, CH3, NH2, NO2, and CN; R9 and R10 are H or alkyl or halo, X1 and Y1 or X2 and Y2, when present, join together to form, independently, a six membered 1N heterocycle substituted with 1-2 R3; or the group: wherein one of W or Z is C=O and the other is C=O, NH, S or O; or when X2 and Y2 are not joined together and when R2 is in the 4-position, then X2 and R2 may join together to form an ethylene bridge; are disclosed.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjL0KwjAURrM4iPoM5gW6KEFcFcWh6OIolNh8rSE_N9xEoW9vEXF1OnA4nKm47WyubLBGJvJDHpy32UFSLx8oYPoZxxSoIwbLTEGO0PGFaO6a8THlGYhta432kOPQg-di0mmfsfhyJpbHw3V_qpCoQU66RURpzpetUiu1qev1_-INTh48ZA</recordid><startdate>19960226</startdate><enddate>19960226</enddate><creator>PATTEN, ARTHUR DAVID</creator><creator>SEITZ, STEVEN PAUL</creator><creator>PACOFSKY, GREGORY JAMES</creator><creator>KALTENBACH III, ROBERT FRANK</creator><creator>ORWAT, MICHAEL JAMES</creator><creator>AKAMIKE, EMEKA AMAECHI</creator><creator>CHERNEY, ROBERT JOSEPH</creator><scope>EVB</scope></search><sort><creationdate>19960226</creationdate><title>Bis-imid polysykliske og heterosykliske kromoforer som er anvendbare som tumoricidale midler</title><author>PATTEN, ARTHUR DAVID ; SEITZ, STEVEN PAUL ; PACOFSKY, GREGORY JAMES ; KALTENBACH III, ROBERT FRANK ; ORWAT, MICHAEL JAMES ; AKAMIKE, EMEKA AMAECHI ; CHERNEY, ROBERT JOSEPH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NO955257LL3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>nor</language><creationdate>1996</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PATTEN, ARTHUR DAVID</creatorcontrib><creatorcontrib>SEITZ, STEVEN PAUL</creatorcontrib><creatorcontrib>PACOFSKY, GREGORY JAMES</creatorcontrib><creatorcontrib>KALTENBACH III, ROBERT FRANK</creatorcontrib><creatorcontrib>ORWAT, MICHAEL JAMES</creatorcontrib><creatorcontrib>AKAMIKE, EMEKA AMAECHI</creatorcontrib><creatorcontrib>CHERNEY, ROBERT JOSEPH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PATTEN, ARTHUR DAVID</au><au>SEITZ, STEVEN PAUL</au><au>PACOFSKY, GREGORY JAMES</au><au>KALTENBACH III, ROBERT FRANK</au><au>ORWAT, MICHAEL JAMES</au><au>AKAMIKE, EMEKA AMAECHI</au><au>CHERNEY, ROBERT JOSEPH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Bis-imid polysykliske og heterosykliske kromoforer som er anvendbare som tumoricidale midler</title><date>1996-02-26</date><risdate>1996</risdate><abstract>Oppfinnelsen angår bis-imid- derivater av tri- og tetraaminer av formel (I) Y1 (D farmasøytiske preparater inneholdende disse og metoder for anvendelse av disse for å behandle kreft, i særdeles- het faste tumorer, i pattedyr.
Anticancer compounds of formula I: (I) and pharmaceutically acceptable salts thereof, wherein: R1, R2 and R3 are independently selected H, CH3, NH2, NO2, and CN; R9 and R10 are H or alkyl or halo, X1 and Y1 or X2 and Y2, when present, join together to form, independently, a six membered 1N heterocycle substituted with 1-2 R3; or the group: wherein one of W or Z is C=O and the other is C=O, NH, S or O; or when X2 and Y2 are not joined together and when R2 is in the 4-position, then X2 and R2 may join together to form an ethylene bridge; are disclosed.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Bis-imid polysykliske og heterosykliske kromoforer som er anvendbare som tumoricidale midler |
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