MIDDEL MOT MAGESAAR
This invention relates to an improved anti-ulcer composition for prophylaxis and treatment of stomach and duodenum ulcers, including stress ulcers. The composition provides potent anti-ulcer activity with a dramatic reduction in toxicity and harmful side effects. The composition comprises a histamin...
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| creator | NIKOLOVA, MILKA P RAKOVSKA, ROSSITZA S LUNA, MILKA A IVANOV, TSHAVDAR BORISSOV BEROVA, NIKOLINA D DRYANSKA, MARGARITA DIMITROVA DALLEVA, LILYANA D ZABUNOVA, ORHIDEYA B MIHAYLOVA, SASCHA R IVANOVA, NEDYALKA STOYANOVA STOYANOVA, MARIA S NISSIMOV, JOSSIF N |
| description | This invention relates to an improved anti-ulcer composition for prophylaxis and treatment of stomach and duodenum ulcers, including stress ulcers. The composition provides potent anti-ulcer activity with a dramatic reduction in toxicity and harmful side effects. The composition comprises a histamine H2 antagonist based on a guanidine derivative, preferably [N-cyano-H'-methyl-N'']-2(4-methyl-imidazolyl)-methylthio-[ethylguanid ine]; and at least one 4-phenyl-tetrahydroisoquinoline antidepressant, preferably the [+] isomer of 4-phenyl-2-methyl-8-amino-1,2,3,4-tetrahydroisoquinoline hydrogen maleate. The composition may also contain a spasmolytic agent, preferably 2-metoxycarbonyl-4-(beta-piperidino ethyl) -metoxycarbonyl-4-(beta-peperidinoethyl) benzophenone. The ratio of antagonist to antidepressant ranges from 2:1 to 60:1, and the ratio of their sum to the spasmolytic agent, when used, ranges from 2.2:1 to 42.5:1. |
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The composition provides potent anti-ulcer activity with a dramatic reduction in toxicity and harmful side effects. The composition comprises a histamine H2 antagonist based on a guanidine derivative, preferably [N-cyano-H'-methyl-N'']-2(4-methyl-imidazolyl)-methylthio-[ethylguanid ine]; and at least one 4-phenyl-tetrahydroisoquinoline antidepressant, preferably the [+] isomer of 4-phenyl-2-methyl-8-amino-1,2,3,4-tetrahydroisoquinoline hydrogen maleate. The composition may also contain a spasmolytic agent, preferably 2-metoxycarbonyl-4-(beta-piperidino ethyl) -metoxycarbonyl-4-(beta-peperidinoethyl) benzophenone. The ratio of antagonist to antidepressant ranges from 2:1 to 60:1, and the ratio of their sum to the spasmolytic agent, when used, ranges from 2.2:1 to 42.5:1.</description><edition>4</edition><language>nor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1985</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19851014&DB=EPODOC&CC=NO&NR=851500L$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19851014&DB=EPODOC&CC=NO&NR=851500L$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NIKOLOVA, MILKA P</creatorcontrib><creatorcontrib>RAKOVSKA, ROSSITZA S</creatorcontrib><creatorcontrib>LUNA, MILKA A</creatorcontrib><creatorcontrib>IVANOV, TSHAVDAR BORISSOV</creatorcontrib><creatorcontrib>BEROVA, NIKOLINA D</creatorcontrib><creatorcontrib>DRYANSKA, MARGARITA DIMITROVA</creatorcontrib><creatorcontrib>DALLEVA, LILYANA D</creatorcontrib><creatorcontrib>ZABUNOVA, ORHIDEYA B</creatorcontrib><creatorcontrib>MIHAYLOVA, SASCHA R</creatorcontrib><creatorcontrib>IVANOVA, NEDYALKA STOYANOVA</creatorcontrib><creatorcontrib>STOYANOVA, MARIA S</creatorcontrib><creatorcontrib>NISSIMOV, JOSSIF N</creatorcontrib><title>MIDDEL MOT MAGESAAR</title><description>This invention relates to an improved anti-ulcer composition for prophylaxis and treatment of stomach and duodenum ulcers, including stress ulcers. The composition provides potent anti-ulcer activity with a dramatic reduction in toxicity and harmful side effects. The composition comprises a histamine H2 antagonist based on a guanidine derivative, preferably [N-cyano-H'-methyl-N'']-2(4-methyl-imidazolyl)-methylthio-[ethylguanid ine]; and at least one 4-phenyl-tetrahydroisoquinoline antidepressant, preferably the [+] isomer of 4-phenyl-2-methyl-8-amino-1,2,3,4-tetrahydroisoquinoline hydrogen maleate. The composition may also contain a spasmolytic agent, preferably 2-metoxycarbonyl-4-(beta-piperidino ethyl) -metoxycarbonyl-4-(beta-peperidinoethyl) benzophenone. 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The composition provides potent anti-ulcer activity with a dramatic reduction in toxicity and harmful side effects. The composition comprises a histamine H2 antagonist based on a guanidine derivative, preferably [N-cyano-H'-methyl-N'']-2(4-methyl-imidazolyl)-methylthio-[ethylguanid ine]; and at least one 4-phenyl-tetrahydroisoquinoline antidepressant, preferably the [+] isomer of 4-phenyl-2-methyl-8-amino-1,2,3,4-tetrahydroisoquinoline hydrogen maleate. The composition may also contain a spasmolytic agent, preferably 2-metoxycarbonyl-4-(beta-piperidino ethyl) -metoxycarbonyl-4-(beta-peperidinoethyl) benzophenone. The ratio of antagonist to antidepressant ranges from 2:1 to 60:1, and the ratio of their sum to the spasmolytic agent, when used, ranges from 2.2:1 to 42.5:1.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | MIDDEL MOT MAGESAAR |
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