Krystallinske solvater og komplekser av (1S)-1,5-anhydro-L-C-(3-((fenyl)metyl)fenyl)-D-glucitol-derivater med aminosyrer som SGLT2-inhibitorer for behandling av diabetes

The present invention relates to a pharmaceutical composition comprising a therapeutically effective amount of a crystalline (2S,3R,4S,5S,6R)-2-[4-chloro-3-(4-ethoxy-benzyl)-phenyl] -6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4,5-triol (S)-propylene glycol solvate (compound Ia) as SGLT2 inhibitor...

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Hauptverfasser: Gougoutas, Jack Z, Wang, Chenchi, Lai, Chiajen, Nirschi, Alexandra A, Dimarco, John D, Bien, Jeffrey T, Singh, Janak, Lobinger, Hildegard, Riebel, Peter, Deshpande, Prashant P, Grosso, John Anthony, Ramakrishnan, Srividya
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creator Gougoutas, Jack Z
Wang, Chenchi
Lai, Chiajen
Nirschi, Alexandra A
Dimarco, John D
Bien, Jeffrey T
Singh, Janak
Lobinger, Hildegard
Riebel, Peter
Deshpande, Prashant P
Grosso, John Anthony
Ramakrishnan, Srividya
description The present invention relates to a pharmaceutical composition comprising a therapeutically effective amount of a crystalline (2S,3R,4S,5S,6R)-2-[4-chloro-3-(4-ethoxy-benzyl)-phenyl] -6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4,5-triol (S)-propylene glycol solvate (compound Ia) as SGLT2 inhibitor for treating diabetes.
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subjects CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
title Krystallinske solvater og komplekser av (1S)-1,5-anhydro-L-C-(3-((fenyl)metyl)fenyl)-D-glucitol-derivater med aminosyrer som SGLT2-inhibitorer for behandling av diabetes
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