Nye hydroksy-6-heteroarylfenantridiner og deres anvendelse som PDE4-inhibitorer
Compounds of formula I in which R1 is methoxy, R2 is methoxy, ethoxy, difluoromethoxy or 2,2-difluoroethoxy, R3 is hydrogen, R31 is hydrogen, R4 is -O-R41, in which R41 is hydrogen, R5 is hydrogen, Har is substituted by R6 and R7, and is pyridinyl, in which R6 is oxo, and R7 is methyl, or an enantio...
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| creator | SCHMIDT BEATE FLOCKERZI DIETER KLEY HANS-PETER BARSIG JOHANNES HATZELMANN ARMIN MARX DEGENHARD ZITT CHRISTOF |
| description | Compounds of formula I
in which
R1 is methoxy,
R2 is methoxy, ethoxy, difluoromethoxy or 2,2-difluoroethoxy,
R3 is hydrogen,
R31 is hydrogen,
R4 is -O-R41, in which
R41 is hydrogen,
R5 is hydrogen,
Har is substituted by R6 and R7, and is pyridinyl, in which
R6 is oxo, and
R7 is methyl,
or an enantiomer, a salt, a N-oxide or a salt of an enantiomer or N-oxide thereof
are novel effective PDE4 inhibitors. |
| format | Patent |
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in which
R1 is methoxy,
R2 is methoxy, ethoxy, difluoromethoxy or 2,2-difluoroethoxy,
R3 is hydrogen,
R31 is hydrogen,
R4 is -O-R41, in which
R41 is hydrogen,
R5 is hydrogen,
Har is substituted by R6 and R7, and is pyridinyl, in which
R6 is oxo, and
R7 is methyl,
or an enantiomer, a salt, a N-oxide or a salt of an enantiomer or N-oxide thereof
are novel effective PDE4 inhibitors.</description><language>nor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150921&DB=EPODOC&CC=NO&NR=336538B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150921&DB=EPODOC&CC=NO&NR=336538B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SCHMIDT BEATE</creatorcontrib><creatorcontrib>FLOCKERZI DIETER</creatorcontrib><creatorcontrib>KLEY HANS-PETER</creatorcontrib><creatorcontrib>BARSIG JOHANNES</creatorcontrib><creatorcontrib>HATZELMANN ARMIN</creatorcontrib><creatorcontrib>MARX DEGENHARD</creatorcontrib><creatorcontrib>ZITT CHRISTOF</creatorcontrib><title>Nye hydroksy-6-heteroarylfenantridiner og deres anvendelse som PDE4-inhibitorer</title><description>Compounds of formula I
in which
R1 is methoxy,
R2 is methoxy, ethoxy, difluoromethoxy or 2,2-difluoroethoxy,
R3 is hydrogen,
R31 is hydrogen,
R4 is -O-R41, in which
R41 is hydrogen,
R5 is hydrogen,
Har is substituted by R6 and R7, and is pyridinyl, in which
R6 is oxo, and
R7 is methyl,
or an enantiomer, a salt, a N-oxide or a salt of an enantiomer or N-oxide thereof
are novel effective PDE4 inhibitors.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjEOwjAQBVE3FAi4w17ABTJE1IEgqoSCPjL4J7YI62htIfn2UHAAqineLFXXFpAvTuIzFV1pjwyJVso0gC1nCS4whOJIDoJElt9ghymBUnzR9dTsdGAf7iFHgazVYrBf3Py6UnRubseLxhx7pNk-wMh92xlT7c2hrrfmj-UDDlY24w</recordid><startdate>20150921</startdate><enddate>20150921</enddate><creator>SCHMIDT BEATE</creator><creator>FLOCKERZI DIETER</creator><creator>KLEY HANS-PETER</creator><creator>BARSIG JOHANNES</creator><creator>HATZELMANN ARMIN</creator><creator>MARX DEGENHARD</creator><creator>ZITT CHRISTOF</creator><scope>EVB</scope></search><sort><creationdate>20150921</creationdate><title>Nye hydroksy-6-heteroarylfenantridiner og deres anvendelse som PDE4-inhibitorer</title><author>SCHMIDT BEATE ; FLOCKERZI DIETER ; KLEY HANS-PETER ; BARSIG JOHANNES ; HATZELMANN ARMIN ; MARX DEGENHARD ; ZITT CHRISTOF</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NO336538BB13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>nor</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SCHMIDT BEATE</creatorcontrib><creatorcontrib>FLOCKERZI DIETER</creatorcontrib><creatorcontrib>KLEY HANS-PETER</creatorcontrib><creatorcontrib>BARSIG JOHANNES</creatorcontrib><creatorcontrib>HATZELMANN ARMIN</creatorcontrib><creatorcontrib>MARX DEGENHARD</creatorcontrib><creatorcontrib>ZITT CHRISTOF</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SCHMIDT BEATE</au><au>FLOCKERZI DIETER</au><au>KLEY HANS-PETER</au><au>BARSIG JOHANNES</au><au>HATZELMANN ARMIN</au><au>MARX DEGENHARD</au><au>ZITT CHRISTOF</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Nye hydroksy-6-heteroarylfenantridiner og deres anvendelse som PDE4-inhibitorer</title><date>2015-09-21</date><risdate>2015</risdate><abstract>Compounds of formula I
in which
R1 is methoxy,
R2 is methoxy, ethoxy, difluoromethoxy or 2,2-difluoroethoxy,
R3 is hydrogen,
R31 is hydrogen,
R4 is -O-R41, in which
R41 is hydrogen,
R5 is hydrogen,
Har is substituted by R6 and R7, and is pyridinyl, in which
R6 is oxo, and
R7 is methyl,
or an enantiomer, a salt, a N-oxide or a salt of an enantiomer or N-oxide thereof
are novel effective PDE4 inhibitors.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Nye hydroksy-6-heteroarylfenantridiner og deres anvendelse som PDE4-inhibitorer |
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