Fremgangsmater for fremstilling av verdifulle terapeutisk aktive piperidinderivater
The present invention is related to novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of formula (I) wherein W represents -C(=O)- or -CH(OH)-; R 1 represents hydrogen or hydroxy; R 2 represents hydrogen; R 1 and R 2 taken together...
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| creator | CARR ALBERT ANTHONY RUDISILL DUANE ERIC KRAUSS RICHARD CARL WOLF RICHARD APPLEBY PANZONE GIANBATTISTA STROM ROBERT MICHAEL KRUPER WILLIAM JOHN SCORTICHINI CAREY LEE WU WEISHI WILSON HAY DAVID ALLEN |
| description | The present invention is related to novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of formula (I) wherein W represents -C(=O)- or -CH(OH)-; R 1 represents hydrogen or hydroxy; R 2 represents hydrogen; R 1 and R 2 taken together form a second bond between the carbon atoms bearing R 1 and R 2 ; n is an integer of from 1 to 5; m is an integer 0 or 1; R 3 is -COOH or -COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R 1 and R 2 are taken together to form a second bond between the carbon atoms bearing R 1 and R 2 or where R 1 represented hydroxy, m is an integer 0. |
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RUDISILL DUANE ERIC ; KRAUSS RICHARD CARL ; WOLF RICHARD APPLEBY ; PANZONE GIANBATTISTA ; STROM ROBERT MICHAEL ; KRUPER WILLIAM JOHN ; SCORTICHINI CAREY LEE ; WU WEISHI WILSON ; HAY DAVID ALLEN</creatorcontrib><description>The present invention is related to novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of formula (I) wherein W represents -C(=O)- or -CH(OH)-; R 1 represents hydrogen or hydroxy; R 2 represents hydrogen; R 1 and R 2 taken together form a second bond between the carbon atoms bearing R 1 and R 2 ; n is an integer of from 1 to 5; m is an integer 0 or 1; R 3 is -COOH or -COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R 1 and R 2 are taken together to form a second bond between the carbon atoms bearing R 1 and R 2 or where R 1 represented hydroxy, m is an integer 0.</description><edition>7</edition><language>nor</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050919&DB=EPODOC&CC=NO&NR=319850B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050919&DB=EPODOC&CC=NO&NR=319850B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CARR ALBERT ANTHONY</creatorcontrib><creatorcontrib>RUDISILL DUANE ERIC</creatorcontrib><creatorcontrib>KRAUSS RICHARD CARL</creatorcontrib><creatorcontrib>WOLF RICHARD APPLEBY</creatorcontrib><creatorcontrib>PANZONE GIANBATTISTA</creatorcontrib><creatorcontrib>STROM ROBERT MICHAEL</creatorcontrib><creatorcontrib>KRUPER WILLIAM JOHN</creatorcontrib><creatorcontrib>SCORTICHINI CAREY LEE</creatorcontrib><creatorcontrib>WU WEISHI WILSON</creatorcontrib><creatorcontrib>HAY DAVID ALLEN</creatorcontrib><title>Fremgangsmater for fremstilling av verdifulle terapeutisk aktive piperidinderivater</title><description>The present invention is related to novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of formula (I) wherein W represents -C(=O)- or -CH(OH)-; 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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Fremgangsmater for fremstilling av verdifulle terapeutisk aktive piperidinderivater |
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