O6-alkylguaninderivater, fremgangsmåte for fremstilling og anvendelse derav samt farmasöytiske preparater
O &cir& _ -hetarylalkyl- or naphthylalkylguanine derivatives of formula (I) wherein Y is H, ribosyl, deoxyribosyl, or R"XCHR"', wherein X is O or S, R'' and R''' are alkyl, or substituted derivatives thereof; R' is H, or alkyl or hydroxyalkyl; R i...
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| creator | KELLY JANE WATSON AMANDA JEAN RAFFERY JOSEPH ANTHONY MCELHINNEY ROBERT STANLEY MARGISON GEOFFREY PAUL MCMURRY THOMAS BRIAN HAMILTON ELDER RHODERICK HUGH MCCORMICK JOAN ELIZABETH WILLINGTON MARK ANDREW |
| description | O &cir& _ -hetarylalkyl- or naphthylalkylguanine derivatives of formula (I) wherein Y is H, ribosyl, deoxyribosyl, or R"XCHR"', wherein X is O or S, R'' and R''' are alkyl, or substituted derivatives thereof; R' is H, or alkyl or hydroxyalkyl; R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring, optionally with a carbocyclic or heterocyclic ring fused thereto, the or each heterocyclic ring having at least one hereto atom chosen from O, N or S, or a substituted derivative thereof; or (ii) naphthyl or a substituted derivative thereof; and pharmaceutically acceptable salts thereof, exhibit the ability to deplete O &cir& _ -alkylguanine-DNA alkyltransferase (ATase) activity. A process for preparation of the compounds is described. The compounds have utility in combination with alkylating agents in the chemotherapeutic treatment of tumour cells. |
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A process for preparation of the compounds is described. The compounds have utility in combination with alkylating agents in the chemotherapeutic treatment of tumour cells.</description><edition>7</edition><language>nor</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>2002</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20020916&DB=EPODOC&CC=NO&NR=313331B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20020916&DB=EPODOC&CC=NO&NR=313331B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KELLY JANE</creatorcontrib><creatorcontrib>WATSON AMANDA JEAN</creatorcontrib><creatorcontrib>RAFFERY JOSEPH ANTHONY</creatorcontrib><creatorcontrib>MCELHINNEY ROBERT STANLEY</creatorcontrib><creatorcontrib>MARGISON GEOFFREY PAUL</creatorcontrib><creatorcontrib>MCMURRY THOMAS BRIAN HAMILTON</creatorcontrib><creatorcontrib>ELDER RHODERICK HUGH</creatorcontrib><creatorcontrib>MCCORMICK JOAN ELIZABETH</creatorcontrib><creatorcontrib>WILLINGTON MARK ANDREW</creatorcontrib><title>O6-alkylguaninderivater, fremgangsmåte for fremstilling og anvendelse derav samt farmasöytiske preparater</title><description>O &cir& _ -hetarylalkyl- or naphthylalkylguanine derivatives of formula (I) wherein Y is H, ribosyl, deoxyribosyl, or R"XCHR"', wherein X is O or S, R'' and R''' are alkyl, or substituted derivatives thereof; R' is H, or alkyl or hydroxyalkyl; R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring, optionally with a carbocyclic or heterocyclic ring fused thereto, the or each heterocyclic ring having at least one hereto atom chosen from O, N or S, or a substituted derivative thereof; or (ii) naphthyl or a substituted derivative thereof; and pharmaceutically acceptable salts thereof, exhibit the ability to deplete O &cir& _ -alkylguanine-DNA alkyltransferase (ATase) activity. 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A process for preparation of the compounds is described. The compounds have utility in combination with alkylating agents in the chemotherapeutic treatment of tumour cells.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | O6-alkylguaninderivater, fremgangsmåte for fremstilling og anvendelse derav samt farmasöytiske preparater |
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