Benzosykloalkylazoltionforbindelser, farmasöytiske preparater og anvendelse av slike forbindelser ved fremstilling avmedikamenter
The present invention relates to novel benzocycloalkylazolethione compounds of formula (I) in which n is 0, 1 or 2; t is 0, 1, 2 or 3; R is independently halo, hydroxy or (C1-4)alkyloxy; and R is attached to the alpha , beta or gamma -position and is a group selected from formulae (a), (b) and (c) w...
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| creator | REPKE, DAVID BRUCE BANSAL, REKHA P WHITING, ROGER L O'YANG, COUNDE MUEHLDORF, ALEXANDER V MARTINEZ, GREGORY R TEITELBAUM, PHILIP J GOODING, OWEN E WALKER, KEITH A. M |
| description | The present invention relates to novel benzocycloalkylazolethione compounds of formula (I) in which n is 0, 1 or 2; t is 0, 1, 2 or 3; R is independently halo, hydroxy or (C1-4)alkyloxy; and R is attached to the alpha , beta or gamma -position and is a group selected from formulae (a), (b) and (c) which are dopamine beta -hydroxylase inhibitors in which the benzocycloalkyl portion of the compound is selected from indanyl, 1,2,3,4-tetrahydronaphthalenyl and 6,7,8,9-tetrahydro-5H-benzocycloheptenyl (in which the benzo is optionally substituted with one to three substituents) and the azolethione portion of the compound is selected from 2-thioxo-2,3-dihydro-1H-imidazol-3-yl, 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-4-yl and 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-1-yl (each optionally substituted with one to three substituents); and the prodrugs, pharmaceutically acceptable salts, individual isomers and mixtures of isomers and the methods of using and preparing such benzocycloalkylazolethione compounds. |
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M</creatorcontrib><description>The present invention relates to novel benzocycloalkylazolethione compounds of formula (I) in which n is 0, 1 or 2; t is 0, 1, 2 or 3; R is independently halo, hydroxy or (C1-4)alkyloxy; and R is attached to the alpha , beta or gamma -position and is a group selected from formulae (a), (b) and (c) which are dopamine beta -hydroxylase inhibitors in which the benzocycloalkyl portion of the compound is selected from indanyl, 1,2,3,4-tetrahydronaphthalenyl and 6,7,8,9-tetrahydro-5H-benzocycloheptenyl (in which the benzo is optionally substituted with one to three substituents) and the azolethione portion of the compound is selected from 2-thioxo-2,3-dihydro-1H-imidazol-3-yl, 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-4-yl and 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-1-yl (each optionally substituted with one to three substituents); and the prodrugs, pharmaceutically acceptable salts, individual isomers and mixtures of isomers and the methods of using and preparing such benzocycloalkylazolethione compounds.</description><edition>7</edition><language>nor</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2002</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20020114&DB=EPODOC&CC=NO&NR=311720B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20020114&DB=EPODOC&CC=NO&NR=311720B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>REPKE, DAVID BRUCE</creatorcontrib><creatorcontrib>BANSAL, REKHA P</creatorcontrib><creatorcontrib>WHITING, ROGER L</creatorcontrib><creatorcontrib>O'YANG, COUNDE</creatorcontrib><creatorcontrib>MUEHLDORF, ALEXANDER V</creatorcontrib><creatorcontrib>MARTINEZ, GREGORY R</creatorcontrib><creatorcontrib>TEITELBAUM, PHILIP J</creatorcontrib><creatorcontrib>GOODING, OWEN E</creatorcontrib><creatorcontrib>WALKER, KEITH A. 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M</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>REPKE, DAVID BRUCE</au><au>BANSAL, REKHA P</au><au>WHITING, ROGER L</au><au>O'YANG, COUNDE</au><au>MUEHLDORF, ALEXANDER V</au><au>MARTINEZ, GREGORY R</au><au>TEITELBAUM, PHILIP J</au><au>GOODING, OWEN E</au><au>WALKER, KEITH A. M</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Benzosykloalkylazoltionforbindelser, farmasöytiske preparater og anvendelse av slike forbindelser ved fremstilling avmedikamenter</title><date>2002-01-14</date><risdate>2002</risdate><abstract>The present invention relates to novel benzocycloalkylazolethione compounds of formula (I) in which n is 0, 1 or 2; t is 0, 1, 2 or 3; R is independently halo, hydroxy or (C1-4)alkyloxy; and R is attached to the alpha , beta or gamma -position and is a group selected from formulae (a), (b) and (c) which are dopamine beta -hydroxylase inhibitors in which the benzocycloalkyl portion of the compound is selected from indanyl, 1,2,3,4-tetrahydronaphthalenyl and 6,7,8,9-tetrahydro-5H-benzocycloheptenyl (in which the benzo is optionally substituted with one to three substituents) and the azolethione portion of the compound is selected from 2-thioxo-2,3-dihydro-1H-imidazol-3-yl, 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-4-yl and 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-1-yl (each optionally substituted with one to three substituents); and the prodrugs, pharmaceutically acceptable salts, individual isomers and mixtures of isomers and the methods of using and preparing such benzocycloalkylazolethione compounds.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Benzosykloalkylazoltionforbindelser, farmasöytiske preparater og anvendelse av slike forbindelser ved fremstilling avmedikamenter |
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