Preparater omfattende dårlig vannløselige farmasøytiske midler og antimikrobielle midler

Preparater omfattende dårlig vannløselige farmasøytiske midler og antimikrobielle midler

Provided herein is a dry composition comprising (a) nanoparticles comprising a poorly water soluble pharmaceutical agent and albumin, and (b) sucrose, wherein the weight ratio of albumin to the poorly water soluble pharmaceutical agent in the composition is 18:1 or less, and wherein the weight ratio...

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Hauptverfasser: Yang, Andrew, Soon-Shiong, Patrick M. D, Selvaraj, Ray, Desai, Neil, P
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Sprache:nor
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator Yang, Andrew
Soon-Shiong, Patrick M. D
Selvaraj, Ray
Desai, Neil, P
description Provided herein is a dry composition comprising (a) nanoparticles comprising a poorly water soluble pharmaceutical agent and albumin, and (b) sucrose, wherein the weight ratio of albumin to the poorly water soluble pharmaceutical agent in the composition is 18:1 or less, and wherein the weight ratio of sucrose to the poorly water soluble pharmaceutical agent in the composition is 7:1, 8:1, 9:1, 10:1 or more. Also provided herein is a liquid suspension comprising (a) nanoparticles comprising a poorly water soluble pharmaceutical agent and albumin, and (b) sucrose, wherein the weight ratio of albumin to the poorly water soluble pharmaceutical agent in said suspension is 18:1 or less, and wherein the concentration of sucrose in said suspension is greater than 50 mg/ml, or is 50 mg/ml to 100 mg/ml. Uses of said compositions in a method of treating cancer in an individual are also provided.
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D ; Selvaraj, Ray ; Desai, Neil, P</creatorcontrib><description>Provided herein is a dry composition comprising (a) nanoparticles comprising a poorly water soluble pharmaceutical agent and albumin, and (b) sucrose, wherein the weight ratio of albumin to the poorly water soluble pharmaceutical agent in the composition is 18:1 or less, and wherein the weight ratio of sucrose to the poorly water soluble pharmaceutical agent in the composition is 7:1, 8:1, 9:1, 10:1 or more. Also provided herein is a liquid suspension comprising (a) nanoparticles comprising a poorly water soluble pharmaceutical agent and albumin, and (b) sucrose, wherein the weight ratio of albumin to the poorly water soluble pharmaceutical agent in said suspension is 18:1 or less, and wherein the concentration of sucrose in said suspension is greater than 50 mg/ml, or is 50 mg/ml to 100 mg/ml. 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Also provided herein is a liquid suspension comprising (a) nanoparticles comprising a poorly water soluble pharmaceutical agent and albumin, and (b) sucrose, wherein the weight ratio of albumin to the poorly water soluble pharmaceutical agent in said suspension is 18:1 or less, and wherein the concentration of sucrose in said suspension is greater than 50 mg/ml, or is 50 mg/ml to 100 mg/ml. 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D</au><au>Selvaraj, Ray</au><au>Desai, Neil, P</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparater omfattende dårlig vannløselige farmasøytiske midler og antimikrobielle midler</title><date>2008-05-13</date><risdate>2008</risdate><abstract>Provided herein is a dry composition comprising (a) nanoparticles comprising a poorly water soluble pharmaceutical agent and albumin, and (b) sucrose, wherein the weight ratio of albumin to the poorly water soluble pharmaceutical agent in the composition is 18:1 or less, and wherein the weight ratio of sucrose to the poorly water soluble pharmaceutical agent in the composition is 7:1, 8:1, 9:1, 10:1 or more. Also provided herein is a liquid suspension comprising (a) nanoparticles comprising a poorly water soluble pharmaceutical agent and albumin, and (b) sucrose, wherein the weight ratio of albumin to the poorly water soluble pharmaceutical agent in said suspension is 18:1 or less, and wherein the concentration of sucrose in said suspension is greater than 50 mg/ml, or is 50 mg/ml to 100 mg/ml. Uses of said compositions in a method of treating cancer in an individual are also provided.</abstract><oa>free_for_read</oa></addata></record>
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Preparater omfattende dårlig vannløselige farmasøytiske midler og antimikrobielle midler
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