Lav hygroskopisk Aripiprazol medikament forbindelse og fremgangsmate for fremstilling derav

Foreliggende oppfinnelse tilveiebringer lav-hygroskopiske former av Aripiprazol og prosesser for fremstilling derav, som ikke omdannes til et hydrat eller taper deres opprinnelige oppløselighet selv når et medisinsk preparat inneholdende Aripiprazolanhydrid-krystallene blir lagret i en forlenget per...

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Hauptverfasser: YAMADA SHOHEI, TOMINAGA MICHIAKI, TAKAHASHI MASANORI, AOKI SATOSHI, FUJIMOTO KIYOSHI, SHINHAMA KOICHI, NISHIOKA YOSHIHIRO, NAKAGAWA TOMONORI, KAWASAKI JUNICHI, TOMIKAWA KENJI, FUJIMURA TSUTOMO, ISHIGAMI MAKOTO, ABE KAORU, TANIGUCHI YOUICHI, KOBAYASHI NORIYUKI, YABUUCHI TSUYOSHI, BANDO TAKUJI, UTSUMI NAOTO, OI YOSHIHIRO
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creator YAMADA SHOHEI
TOMINAGA MICHIAKI
TAKAHASHI MASANORI
AOKI SATOSHI
FUJIMOTO KIYOSHI
SHINHAMA KOICHI
NISHIOKA YOSHIHIRO
NAKAGAWA TOMONORI
KAWASAKI JUNICHI
TOMIKAWA KENJI
FUJIMURA TSUTOMO
ISHIGAMI MAKOTO
ABE KAORU
TANIGUCHI YOUICHI
KOBAYASHI NORIYUKI
YABUUCHI TSUYOSHI
BANDO TAKUJI
UTSUMI NAOTO
OI YOSHIHIRO
description Foreliggende oppfinnelse tilveiebringer lav-hygroskopiske former av Aripiprazol og prosesser for fremstilling derav, som ikke omdannes til et hydrat eller taper deres opprinnelige oppløselighet selv når et medisinsk preparat inneholdende Aripiprazolanhydrid-krystallene blir lagret i en forlenget periode. The present invention provides an improved low hygroscopic form, form E, of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SEPARATION
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TRANSPORTING
title Lav hygroskopisk Aripiprazol medikament forbindelse og fremgangsmate for fremstilling derav
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