Doseringsplan for ERBB2 antikreftmidler

Det beskrives metoder for behandling av overekspresjon av erbB2 i et pattedyr som trenger behandling, ved administrering til pattedyret en terapeutisk effektiv mengde av en første inhibitor av en erbB2-reseptor og så, etter et intervall på mindre enn 24 timer, administrering til pattedyret av fra 1...

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Hauptverfasser: NOE DENNIS ALAN, CONNELL RICHARD DAMIAN, MOYER JAMES DALE, JANI JITESH PRANLAL, BHATTACHARYA SAMIT KUMAR, STEYN STEFANUS JOHANNES
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creator NOE DENNIS ALAN
CONNELL RICHARD DAMIAN
MOYER JAMES DALE
JANI JITESH PRANLAL
BHATTACHARYA SAMIT KUMAR
STEYN STEFANUS JOHANNES
description Det beskrives metoder for behandling av overekspresjon av erbB2 i et pattedyr som trenger behandling, ved administrering til pattedyret en terapeutisk effektiv mengde av en første inhibitor av en erbB2-reseptor og så, etter et intervall på mindre enn 24 timer, administrering til pattedyret av fra 1 til 6 terapeutisk effektive mengder av den samme eller en annen inhibitor av erbB2-reseptoren. Oppfinnelsen er også rettet mot en langsom, daglig infusjon av erbB2-inhibitoren. Overekspresjonen av erbB2-reseptoren kan resultere i anormal cellevekst og føre til cancer. Ved oppfinnelsens metoder økes effektiviteten og sikkerheten ved inhibitorene. Det beskrives videre sett som letter doseadministreringen ifølge oppfinnelsen. The invention is directed to methods for the a method for treating overexpression of the erbB2 in a mammal in need of treatment by administering to the mammal a therapeutically effective amount of a first inhibitor of an erbB2 receptor and then, after an interval of less than 24 hours, administering to the mammal from one to six therapeutically effective amounts of the same or different inhibitor of the erbB2 receptor. The invention is also directed to a slow daily infusion of the erbB2 inhibitor. The overexpression of the erbB2 receptor can result in abnormal cell growth and lead to cancer. By the methods of the invention, the efficacy and safety of the inhibitors is increased. The invention is also directed to kits for facilitating the dose administration method of the invention.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Doseringsplan for ERBB2 antikreftmidler
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