3-amino-tieno[2,3-b]pyridin-2-karboksysyreamid-forbindelser og fremgangsmater for fremstilling og anvendelser av dem
Beskrevet er forbindelser med formel (I), hvor R1 og R2 er definert her, som er anvendelige som inhibitorer av kinaseaktiviteten til IkB kinase(IKK)komplekset. Forbindelsene er derfor anvendelige ved behandling av IKK-medierte sykdommer omfattende autoimmune sykdommer, inflammatoriske sykdommer og k...
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| creator | NEMOTO PETER LIU WILL WEIMIN SUN SANXING HAO MING HONG WU JIANG-PING FLECK ROMAN WOLFGANG SORCEK RONALD J HICKEY EUGENE RICHARD CYWIN CHARLES EMEIGH JONATHAN MARSHALL DANIEL R MORWICK TINA MARIE CHEN ZHIDONG |
| description | Beskrevet er forbindelser med formel (I), hvor R1 og R2 er definert her, som er anvendelige som inhibitorer av kinaseaktiviteten til IkB kinase(IKK)komplekset. Forbindelsene er derfor anvendelige ved behandling av IKK-medierte sykdommer omfattende autoimmune sykdommer, inflammatoriske sykdommer og kreft. Beskrevet er også farmasøytiske preparater omfattende disse forbindelser og fremgangsmåter for fremstilling av disse.
Disclosed are compounds of formula (I):
wherein R 1 and R 2 are defined herein, which are useful as inhibitors of the kinase activity of the IºB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds. |
| format | Patent |
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Disclosed are compounds of formula (I):
wherein R 1 and R 2 are defined herein, which are useful as inhibitors of the kinase activity of the IºB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.</description><edition>7</edition><language>nor</language><subject>APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050216&DB=EPODOC&CC=NO&NR=20044599L$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050216&DB=EPODOC&CC=NO&NR=20044599L$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NEMOTO PETER</creatorcontrib><creatorcontrib>LIU WILL WEIMIN</creatorcontrib><creatorcontrib>SUN SANXING</creatorcontrib><creatorcontrib>HAO MING HONG</creatorcontrib><creatorcontrib>WU JIANG-PING</creatorcontrib><creatorcontrib>FLECK ROMAN WOLFGANG</creatorcontrib><creatorcontrib>SORCEK RONALD J</creatorcontrib><creatorcontrib>HICKEY EUGENE RICHARD</creatorcontrib><creatorcontrib>CYWIN CHARLES</creatorcontrib><creatorcontrib>EMEIGH JONATHAN</creatorcontrib><creatorcontrib>MARSHALL DANIEL R</creatorcontrib><creatorcontrib>MORWICK TINA MARIE</creatorcontrib><creatorcontrib>CHEN ZHIDONG</creatorcontrib><title>3-amino-tieno[2,3-b]pyridin-2-karboksysyreamid-forbindelser og fremgangsmater for fremstilling og anvendelser av dem</title><description>Beskrevet er forbindelser med formel (I), hvor R1 og R2 er definert her, som er anvendelige som inhibitorer av kinaseaktiviteten til IkB kinase(IKK)komplekset. Forbindelsene er derfor anvendelige ved behandling av IKK-medierte sykdommer omfattende autoimmune sykdommer, inflammatoriske sykdommer og kreft. Beskrevet er også farmasøytiske preparater omfattende disse forbindelser og fremgangsmåter for fremstilling av disse.
Disclosed are compounds of formula (I):
wherein R 1 and R 2 are defined herein, which are useful as inhibitors of the kinase activity of the IºB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.</description><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi7EKwkAQRNNYiPoPsXchJLFILYpF0MZOJGy8zbEktxfujkD-3lO0txrmzZtlEgpAw2IhMIm957sC2sc4O1YskEOPrrW9n_3sKHoKOutaFkWDJ5danXaOjEbR3mCIJM4f5AMPA4t-KygT_R44pYrMOll0GPvmm6tkezreDmeg0TbkR3ySUGgu1zzLynJfVXVd_OO8AHyRRVA</recordid><startdate>20050216</startdate><enddate>20050216</enddate><creator>NEMOTO PETER</creator><creator>LIU WILL WEIMIN</creator><creator>SUN SANXING</creator><creator>HAO MING HONG</creator><creator>WU JIANG-PING</creator><creator>FLECK ROMAN WOLFGANG</creator><creator>SORCEK RONALD J</creator><creator>HICKEY EUGENE RICHARD</creator><creator>CYWIN CHARLES</creator><creator>EMEIGH JONATHAN</creator><creator>MARSHALL DANIEL R</creator><creator>MORWICK TINA MARIE</creator><creator>CHEN ZHIDONG</creator><scope>EVB</scope></search><sort><creationdate>20050216</creationdate><title>3-amino-tieno[2,3-b]pyridin-2-karboksysyreamid-forbindelser og fremgangsmater for fremstilling og anvendelser av dem</title><author>NEMOTO PETER ; LIU WILL WEIMIN ; SUN SANXING ; HAO MING HONG ; WU JIANG-PING ; FLECK ROMAN WOLFGANG ; SORCEK RONALD J ; HICKEY EUGENE RICHARD ; CYWIN CHARLES ; EMEIGH JONATHAN ; MARSHALL DANIEL R ; MORWICK TINA MARIE ; CHEN ZHIDONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NO20044599LL3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>nor</language><creationdate>2005</creationdate><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>NEMOTO PETER</creatorcontrib><creatorcontrib>LIU WILL WEIMIN</creatorcontrib><creatorcontrib>SUN SANXING</creatorcontrib><creatorcontrib>HAO MING HONG</creatorcontrib><creatorcontrib>WU JIANG-PING</creatorcontrib><creatorcontrib>FLECK ROMAN WOLFGANG</creatorcontrib><creatorcontrib>SORCEK RONALD J</creatorcontrib><creatorcontrib>HICKEY EUGENE RICHARD</creatorcontrib><creatorcontrib>CYWIN CHARLES</creatorcontrib><creatorcontrib>EMEIGH JONATHAN</creatorcontrib><creatorcontrib>MARSHALL DANIEL R</creatorcontrib><creatorcontrib>MORWICK TINA MARIE</creatorcontrib><creatorcontrib>CHEN ZHIDONG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NEMOTO PETER</au><au>LIU WILL WEIMIN</au><au>SUN SANXING</au><au>HAO MING HONG</au><au>WU JIANG-PING</au><au>FLECK ROMAN WOLFGANG</au><au>SORCEK RONALD J</au><au>HICKEY EUGENE RICHARD</au><au>CYWIN CHARLES</au><au>EMEIGH JONATHAN</au><au>MARSHALL DANIEL R</au><au>MORWICK TINA MARIE</au><au>CHEN ZHIDONG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>3-amino-tieno[2,3-b]pyridin-2-karboksysyreamid-forbindelser og fremgangsmater for fremstilling og anvendelser av dem</title><date>2005-02-16</date><risdate>2005</risdate><abstract>Beskrevet er forbindelser med formel (I), hvor R1 og R2 er definert her, som er anvendelige som inhibitorer av kinaseaktiviteten til IkB kinase(IKK)komplekset. Forbindelsene er derfor anvendelige ved behandling av IKK-medierte sykdommer omfattende autoimmune sykdommer, inflammatoriske sykdommer og kreft. Beskrevet er også farmasøytiske preparater omfattende disse forbindelser og fremgangsmåter for fremstilling av disse.
Disclosed are compounds of formula (I):
wherein R 1 and R 2 are defined herein, which are useful as inhibitors of the kinase activity of the IºB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 3-amino-tieno[2,3-b]pyridin-2-karboksysyreamid-forbindelser og fremgangsmater for fremstilling og anvendelser av dem |
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