2-oksasolaminer og deres anvendelse som 5-HT2B reseptor antagonister
The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl...
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| creator | HARRIS NEIL VICTOR ALEY AMANDA CLARK LYLE KENNETH ARCHER ANN JANET BORMAN ANTHONY RICHARD OXFORD ALEXANDER WILLIAM HYND GEORGE |
| description | The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl group; R2 and R3 are either: (i) independently selected from H, R, R', SO2R, C(-O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R' is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HT2B receptor. |
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OXFORD ALEXANDER WILLIAM ; HYND GEORGE</creatorcontrib><description>The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl group; R2 and R3 are either: (i) independently selected from H, R, R', SO2R, C(-O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R' is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HT2B receptor.</description><edition>7</edition><language>nor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040910&DB=EPODOC&CC=NO&NR=20043799L$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040910&DB=EPODOC&CC=NO&NR=20043799L$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HARRIS NEIL VICTOR</creatorcontrib><creatorcontrib>ALEY AMANDA</creatorcontrib><creatorcontrib>CLARK LYLE KENNETH</creatorcontrib><creatorcontrib>ARCHER ANN JANET</creatorcontrib><creatorcontrib>BORMAN ANTHONY RICHARD</creatorcontrib><creatorcontrib>OXFORD ALEXANDER WILLIAM</creatorcontrib><creatorcontrib>HYND GEORGE</creatorcontrib><title>2-oksasolaminer og deres anvendelse som 5-HT2B reseptor antagonister</title><description>The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl group; R2 and R3 are either: (i) independently selected from H, R, R', SO2R, C(-O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R' is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HT2B receptor.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAx0s3PLk4szs9JzM3MSy1SyE9XSEktSi1WSMwrS81LSc0pTlUozs9VMNX1CDFyUgDKpBaU5BcBpUsS0_PzMotLUot4GFjTEoEKeaE0N4Oim2uIs4duakF-fGpxQWJyal5qSbyfv5GBgYmxuaWlj48xMWoAbg0yng</recordid><startdate>20040910</startdate><enddate>20040910</enddate><creator>HARRIS NEIL VICTOR</creator><creator>ALEY AMANDA</creator><creator>CLARK LYLE KENNETH</creator><creator>ARCHER ANN JANET</creator><creator>BORMAN ANTHONY RICHARD</creator><creator>OXFORD ALEXANDER WILLIAM</creator><creator>HYND GEORGE</creator><scope>EVB</scope></search><sort><creationdate>20040910</creationdate><title>2-oksasolaminer og deres anvendelse som 5-HT2B reseptor antagonister</title><author>HARRIS NEIL VICTOR ; ALEY AMANDA ; CLARK LYLE KENNETH ; ARCHER ANN JANET ; BORMAN ANTHONY RICHARD ; OXFORD ALEXANDER WILLIAM ; HYND GEORGE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NO20043799LL3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>nor</language><creationdate>2004</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HARRIS NEIL VICTOR</creatorcontrib><creatorcontrib>ALEY AMANDA</creatorcontrib><creatorcontrib>CLARK LYLE KENNETH</creatorcontrib><creatorcontrib>ARCHER ANN JANET</creatorcontrib><creatorcontrib>BORMAN ANTHONY RICHARD</creatorcontrib><creatorcontrib>OXFORD ALEXANDER WILLIAM</creatorcontrib><creatorcontrib>HYND GEORGE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HARRIS NEIL VICTOR</au><au>ALEY AMANDA</au><au>CLARK LYLE KENNETH</au><au>ARCHER ANN JANET</au><au>BORMAN ANTHONY RICHARD</au><au>OXFORD ALEXANDER WILLIAM</au><au>HYND GEORGE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>2-oksasolaminer og deres anvendelse som 5-HT2B reseptor antagonister</title><date>2004-09-10</date><risdate>2004</risdate><abstract>The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl group; R2 and R3 are either: (i) independently selected from H, R, R', SO2R, C(-O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R' is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HT2B receptor.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 2-oksasolaminer og deres anvendelse som 5-HT2B reseptor antagonister |
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