Beta disubstituerte metallproteaseinhibitorer
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to Formula (I), wherein R , R , R , R , R , R , G and Z have the meanings describ...
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| creator | OHLER, NORMAN EUGENE NATCHUS, MICHAEL GEORGE DE, BISWANATH PIKUL, STANISLAW ALMSTEAD, NEIL GREGORY SOLINSKY, KELLY MICHELLE |
| description | Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to Formula (I), wherein R , R , R , R , R , R , G and Z have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of Formula (I), and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions. |
| format | Patent |
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In particular, the compounds have a structure according to Formula (I), wherein R , R , R , R , R , R , G and Z have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of Formula (I), and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.</description><edition>7</edition><language>nor</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2002</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20020614&DB=EPODOC&CC=NO&NR=20021748L$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20020614&DB=EPODOC&CC=NO&NR=20021748L$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OHLER, NORMAN EUGENE</creatorcontrib><creatorcontrib>NATCHUS, MICHAEL GEORGE</creatorcontrib><creatorcontrib>DE, BISWANATH</creatorcontrib><creatorcontrib>PIKUL, STANISLAW</creatorcontrib><creatorcontrib>ALMSTEAD, NEIL GREGORY</creatorcontrib><creatorcontrib>SOLINSKY, KELLY MICHELLE</creatorcontrib><title>Beta disubstituerte metallproteaseinhibitorer</title><description>Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to Formula (I), wherein R , R , R , R , R , R , G and Z have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of Formula (I), and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2002</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB1Si1JVEjJLC5NKi7JLClNLSpJVcgFiuXkFBTll6QmFqdm5mVkJmWW5BelFvEwsKYl5hSn8kJpbgZFN9cQZw_d1IL8-NTigsTk1LzUkng_fyMDAyNDcxMLHx9jYtQAAEbVK6c</recordid><startdate>20020614</startdate><enddate>20020614</enddate><creator>OHLER, NORMAN EUGENE</creator><creator>NATCHUS, MICHAEL GEORGE</creator><creator>DE, BISWANATH</creator><creator>PIKUL, STANISLAW</creator><creator>ALMSTEAD, NEIL GREGORY</creator><creator>SOLINSKY, KELLY MICHELLE</creator><scope>EVB</scope></search><sort><creationdate>20020614</creationdate><title>Beta disubstituerte metallproteaseinhibitorer</title><author>OHLER, NORMAN EUGENE ; NATCHUS, MICHAEL GEORGE ; DE, BISWANATH ; PIKUL, STANISLAW ; ALMSTEAD, NEIL GREGORY ; SOLINSKY, KELLY MICHELLE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NO20021748LL3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>nor</language><creationdate>2002</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>OHLER, NORMAN EUGENE</creatorcontrib><creatorcontrib>NATCHUS, MICHAEL GEORGE</creatorcontrib><creatorcontrib>DE, BISWANATH</creatorcontrib><creatorcontrib>PIKUL, STANISLAW</creatorcontrib><creatorcontrib>ALMSTEAD, NEIL GREGORY</creatorcontrib><creatorcontrib>SOLINSKY, KELLY MICHELLE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OHLER, NORMAN EUGENE</au><au>NATCHUS, MICHAEL GEORGE</au><au>DE, BISWANATH</au><au>PIKUL, STANISLAW</au><au>ALMSTEAD, NEIL GREGORY</au><au>SOLINSKY, KELLY MICHELLE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Beta disubstituerte metallproteaseinhibitorer</title><date>2002-06-14</date><risdate>2002</risdate><abstract>Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to Formula (I), wherein R , R , R , R , R , R , G and Z have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of Formula (I), and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Beta disubstituerte metallproteaseinhibitorer |
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