Benzisoksazolyl-, pyridolisoksazolyl- og benztienyl- fenoksyderivater anvendbare som D4-antagonister

The compounds are of the class of benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These conditions comprise, for example, Attention Deficit Hyper...

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Hauptverfasser: HENDRIX, JAMES A, HANNA, REDA G, HRIB, NICHOLAS JOSEPH, SHUTSKE, GREGORY M, FREED, BRIAN SCOTT, TOMER IV, JOHN D, JURCAK, JOHN G
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creator HENDRIX, JAMES A
HANNA, REDA G
HRIB, NICHOLAS JOSEPH
SHUTSKE, GREGORY M
FREED, BRIAN SCOTT
TOMER IV, JOHN D
JURCAK, JOHN G
description The compounds are of the class of benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Benzisoksazolyl-, pyridolisoksazolyl- og benztienyl- fenoksyderivater anvendbare som D4-antagonister
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