Proteaseinhibitorer

Den foreliggende oppfinnelse tilveiebringer forbindelser som inhiberer proteaser, innbefattet kathepsin K,og farmasøytiske blandinger som inneholder slike forbindelser. Disse kan anvendes for behandling av sykdommer med for høyt bentap eller brusk- eller matriks-nedbrytning, innbefattet osteoporose;...

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Hauptverfasser:	THOMPSON, SCOTT KEVIN, VEBER, DANIEL FRANK, DESJARLAIS, RENEE LOUISE, CARR, THOMAS JOSEPH, GALLAGHER, TIMOTHY FRANCIS, YAMASHITA, DENNIS SHINJI, HALBERT, STACIE MARIE, YEN, JACK HWEKWO, OH, HYE-JA
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Sprache:	nor
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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creator	THOMPSON, SCOTT KEVIN VEBER, DANIEL FRANK DESJARLAIS, RENEE LOUISE CARR, THOMAS JOSEPH GALLAGHER, TIMOTHY FRANCIS YAMASHITA, DENNIS SHINJI HALBERT, STACIE MARIE YEN, JACK HWEKWO OH, HYE-JA
description	Den foreliggende oppfinnelse tilveiebringer forbindelser som inhiberer proteaser, innbefattet kathepsin K,og farmasøytiske blandinger som inneholder slike forbindelser. Disse kan anvendes for behandling av sykdommer med for høyt bentap eller brusk- eller matriks-nedbrytning, innbefattet osteoporose; artritt, nærmere bestemt osteoartritt og reumatoid artritt; og metabolsk bensykdom, omfattende inhibering av nevnte bentap eller alt for høye brusk- eller matriks- nedbrytning ved administrering til en pasient med behov for dette av en forbindelse ifølge den foreliggende oppfinnelse. Disclosed herein is a compound of the formula known as 2-[N-(N-benzyloxycarbonyl-L-leucinyl)]-2'-[N'-[4-(N,N-dimethylaminomethyl)benzyloxy]carbonyl-L-leucinyl]carbohydrazide; and pharmaceutically acceptable salts, hydrates and solvates thereof.
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Disse kan anvendes for behandling av sykdommer med for høyt bentap eller brusk- eller matriks-nedbrytning, innbefattet osteoporose; artritt, nærmere bestemt osteoartritt og reumatoid artritt; og metabolsk bensykdom, omfattende inhibering av nevnte bentap eller alt for høye brusk- eller matriks- nedbrytning ved administrering til en pasient med behov for dette av en forbindelse ifølge den foreliggende oppfinnelse. Disclosed herein is a compound of the formula known as 2-[N-(N-benzyloxycarbonyl-L-leucinyl)]-2'-[N'-[4-(N,N-dimethylaminomethyl)benzyloxy]carbonyl-L-leucinyl]carbohydrazide; and pharmaceutically acceptable salts, hydrates and solvates thereof.</description><edition>7</edition><language>nor</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>1998</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980629&DB=EPODOC&CC=NO&NR=20006717L$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980629&DB=EPODOC&CC=NO&NR=20006717L$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>THOMPSON, SCOTT KEVIN</creatorcontrib><creatorcontrib>VEBER, DANIEL FRANK</creatorcontrib><creatorcontrib>DESJARLAIS, RENEE LOUISE</creatorcontrib><creatorcontrib>CARR, THOMAS JOSEPH</creatorcontrib><creatorcontrib>GALLAGHER, TIMOTHY FRANCIS</creatorcontrib><creatorcontrib>YAMASHITA, DENNIS SHINJI</creatorcontrib><creatorcontrib>HALBERT, STACIE MARIE</creatorcontrib><creatorcontrib>YEN, JACK HWEKWO</creatorcontrib><creatorcontrib>OH, HYE-JA</creatorcontrib><title>Proteaseinhibitorer</title><description>Den foreliggende oppfinnelse tilveiebringer forbindelser som inhiberer proteaser, innbefattet kathepsin K,og farmasøytiske blandinger som inneholder slike forbindelser. 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Disclosed herein is a compound of the formula known as 2-[N-(N-benzyloxycarbonyl-L-leucinyl)]-2'-[N'-[4-(N,N-dimethylaminomethyl)benzyloxy]carbonyl-L-leucinyl]carbohydrazide; and pharmaceutically acceptable salts, hydrates and solvates thereof.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1998</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBAOKMovSU0sTs3My8hMyizJL0ot4mFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8X7-RgYGBmbmhuY-PsbEqAEAWnshMA</recordid><startdate>19980629</startdate><enddate>19980629</enddate><creator>THOMPSON, SCOTT KEVIN</creator><creator>VEBER, DANIEL FRANK</creator><creator>DESJARLAIS, RENEE LOUISE</creator><creator>CARR, THOMAS JOSEPH</creator><creator>GALLAGHER, TIMOTHY FRANCIS</creator><creator>YAMASHITA, DENNIS SHINJI</creator><creator>HALBERT, STACIE MARIE</creator><creator>YEN, JACK HWEKWO</creator><creator>OH, HYE-JA</creator><scope>EVB</scope></search><sort><creationdate>19980629</creationdate><title>Proteaseinhibitorer</title><author>THOMPSON, SCOTT KEVIN ; VEBER, DANIEL FRANK ; DESJARLAIS, RENEE LOUISE ; CARR, THOMAS JOSEPH ; GALLAGHER, TIMOTHY FRANCIS ; YAMASHITA, DENNIS SHINJI ; HALBERT, STACIE MARIE ; YEN, JACK HWEKWO ; OH, HYE-JA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NO20006717LL3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>nor</language><creationdate>1998</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>THOMPSON, SCOTT KEVIN</creatorcontrib><creatorcontrib>VEBER, DANIEL FRANK</creatorcontrib><creatorcontrib>DESJARLAIS, RENEE LOUISE</creatorcontrib><creatorcontrib>CARR, THOMAS JOSEPH</creatorcontrib><creatorcontrib>GALLAGHER, TIMOTHY FRANCIS</creatorcontrib><creatorcontrib>YAMASHITA, DENNIS SHINJI</creatorcontrib><creatorcontrib>HALBERT, STACIE MARIE</creatorcontrib><creatorcontrib>YEN, JACK HWEKWO</creatorcontrib><creatorcontrib>OH, HYE-JA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>THOMPSON, SCOTT KEVIN</au><au>VEBER, DANIEL FRANK</au><au>DESJARLAIS, RENEE LOUISE</au><au>CARR, THOMAS JOSEPH</au><au>GALLAGHER, TIMOTHY FRANCIS</au><au>YAMASHITA, DENNIS SHINJI</au><au>HALBERT, STACIE MARIE</au><au>YEN, JACK HWEKWO</au><au>OH, HYE-JA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Proteaseinhibitorer</title><date>1998-06-29</date><risdate>1998</risdate><abstract>Den foreliggende oppfinnelse tilveiebringer forbindelser som inhiberer proteaser, innbefattet kathepsin K,og farmasøytiske blandinger som inneholder slike forbindelser. Disse kan anvendes for behandling av sykdommer med for høyt bentap eller brusk- eller matriks-nedbrytning, innbefattet osteoporose; artritt, nærmere bestemt osteoartritt og reumatoid artritt; og metabolsk bensykdom, omfattende inhibering av nevnte bentap eller alt for høye brusk- eller matriks- nedbrytning ved administrering til en pasient med behov for dette av en forbindelse ifølge den foreliggende oppfinnelse. Disclosed herein is a compound of the formula known as 2-[N-(N-benzyloxycarbonyl-L-leucinyl)]-2'-[N'-[4-(N,N-dimethylaminomethyl)benzyloxy]carbonyl-L-leucinyl]carbohydrazide; and pharmaceutically acceptable salts, hydrates and solvates thereof.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record>
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subjects	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
title	Proteaseinhibitorer
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