DNA-vektor for ekspresjon av desulfatohirudin i gjær eller E.coli samt fremgangsmåte for fremstilling av desulfatohirudin og salter derav

The invention relates to DNA sequences which code for the amino-acid sequence of the thrombin inhibitor hirudin, to hybrid vectors containing such DNA sequences, to host cells transformed with such hybrid vectors, to polypeptides produced by such transformed host cells and having thrombin inhibitory...

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Hauptverfasser: MEYHACK, BERND, RINK, HANS, GRUTTER, MARKUS GERHARD, LIERSCH, MANFRED, MARKI, WALTER
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creator MEYHACK, BERND
RINK, HANS
GRUTTER, MARKUS GERHARD
LIERSCH, MANFRED
MARKI, WALTER
description The invention relates to DNA sequences which code for the amino-acid sequence of the thrombin inhibitor hirudin, to hybrid vectors containing such DNA sequences, to host cells transformed with such hybrid vectors, to polypeptides produced by such transformed host cells and having thrombin inhibitory activity, to processes for preparing these DNA sequences, hybrid vectors and transformed host cells and processes for preparing these thrombin inhibitors using the transformed host cells. The hirudin compounds have valuable pharmacological properties.
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DERIVATIVES THEREOF
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
SUGARS
TESTING
VINEGAR
WINE
title DNA-vektor for ekspresjon av desulfatohirudin i gjær eller E.coli samt fremgangsmåte for fremstilling av desulfatohirudin og salter derav
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