ANALOGIFREMGANGSMTE VED FREMSTILLING AV TERAPEUTISK AKTIVE 7-BROM-5-(2-HALOGENFENYL)-1H-2,3-DIHYDRO-1,4-BENZODIAZEPINFORBINDELSER
Disclosed are 7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines of the formula I I in which R1 is a hydrogen atom or a lower alkoxy or alkanoyloxy radical and R2 is a halogen atom. The compounds possess psychopharmacological, and especially anti-aggressive properties. To manufacture compou...
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| creator | ZEUGNER, HORST MUSCH, HERBERT RUHLAND, MICHAEL MILKOWSKI, WOLFGANG LIEPMANN, HANS |
| description | Disclosed are 7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines of the formula I I in which R1 is a hydrogen atom or a lower alkoxy or alkanoyloxy radical and R2 is a halogen atom. The compounds possess psychopharmacological, and especially anti-aggressive properties. To manufacture compounds of formula I, corresponding 2-halomethyl-7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines are cyclized to corresponding 7-bromo-1,2-methylene-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines and in these the aziridine ring is opened through treatment with a lower alcohol or a lower carboxylic acid in the presence of a Lewis acid. |
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The compounds possess psychopharmacological, and especially anti-aggressive properties. To manufacture compounds of formula I, corresponding 2-halomethyl-7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines are cyclized to corresponding 7-bromo-1,2-methylene-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines and in these the aziridine ring is opened through treatment with a lower alcohol or a lower carboxylic acid in the presence of a Lewis acid.</description><edition>4</edition><language>nor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1988</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19880125&DB=EPODOC&CC=NO&NR=157698B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25551,76302</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19880125&DB=EPODOC&CC=NO&NR=157698B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZEUGNER, HORST</creatorcontrib><creatorcontrib>MUSCH, HERBERT</creatorcontrib><creatorcontrib>RUHLAND, MICHAEL</creatorcontrib><creatorcontrib>MILKOWSKI, WOLFGANG</creatorcontrib><creatorcontrib>LIEPMANN, HANS</creatorcontrib><title>ANALOGIFREMGANGSMTE VED FREMSTILLING AV TERAPEUTISK AKTIVE 7-BROM-5-(2-HALOGENFENYL)-1H-2,3-DIHYDRO-1,4-BENZODIAZEPINFORBINDELSER</title><description>Disclosed are 7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines of the formula I I in which R1 is a hydrogen atom or a lower alkoxy or alkanoyloxy radical and R2 is a halogen atom. The compounds possess psychopharmacological, and especially anti-aggressive properties. To manufacture compounds of formula I, corresponding 2-halomethyl-7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines are cyclized to corresponding 7-bromo-1,2-methylene-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines and in these the aziridine ring is opened through treatment with a lower alcohol or a lower carboxylic acid in the presence of a Lewis acid.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1988</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjDsKwkAUANNYiHoGt1TwFYnGT7nrviQPN2_DZg1oIyJrJSroDTyId_FkErC3GhiG6UYvydLYnDKHZS45r8vP26NoUItW1Z6MIc6FbIRHJyvceqo3Qm48NSgWoJwtIYVRAkX7Qc6Qd2YMcQHJZAqaip12FuLJDBTy3mqSe6yIM-sUsUZTo-tHnfPx8giDH3vRMEO_LiDcb4fwuB9P4RqeB7ZxupivlkpN_xdfpQg80g</recordid><startdate>19880125</startdate><enddate>19880125</enddate><creator>ZEUGNER, HORST</creator><creator>MUSCH, HERBERT</creator><creator>RUHLAND, MICHAEL</creator><creator>MILKOWSKI, WOLFGANG</creator><creator>LIEPMANN, HANS</creator><scope>EVB</scope></search><sort><creationdate>19880125</creationdate><title>ANALOGIFREMGANGSMTE VED FREMSTILLING AV TERAPEUTISK AKTIVE 7-BROM-5-(2-HALOGENFENYL)-1H-2,3-DIHYDRO-1,4-BENZODIAZEPINFORBINDELSER</title><author>ZEUGNER, HORST ; MUSCH, HERBERT ; RUHLAND, MICHAEL ; MILKOWSKI, WOLFGANG ; LIEPMANN, HANS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NO157698BB3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>nor</language><creationdate>1988</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZEUGNER, HORST</creatorcontrib><creatorcontrib>MUSCH, HERBERT</creatorcontrib><creatorcontrib>RUHLAND, MICHAEL</creatorcontrib><creatorcontrib>MILKOWSKI, WOLFGANG</creatorcontrib><creatorcontrib>LIEPMANN, HANS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZEUGNER, HORST</au><au>MUSCH, HERBERT</au><au>RUHLAND, MICHAEL</au><au>MILKOWSKI, WOLFGANG</au><au>LIEPMANN, HANS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANALOGIFREMGANGSMTE VED FREMSTILLING AV TERAPEUTISK AKTIVE 7-BROM-5-(2-HALOGENFENYL)-1H-2,3-DIHYDRO-1,4-BENZODIAZEPINFORBINDELSER</title><date>1988-01-25</date><risdate>1988</risdate><abstract>Disclosed are 7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines of the formula I I in which R1 is a hydrogen atom or a lower alkoxy or alkanoyloxy radical and R2 is a halogen atom. The compounds possess psychopharmacological, and especially anti-aggressive properties. To manufacture compounds of formula I, corresponding 2-halomethyl-7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines are cyclized to corresponding 7-bromo-1,2-methylene-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines and in these the aziridine ring is opened through treatment with a lower alcohol or a lower carboxylic acid in the presence of a Lewis acid.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ANALOGIFREMGANGSMTE VED FREMSTILLING AV TERAPEUTISK AKTIVE 7-BROM-5-(2-HALOGENFENYL)-1H-2,3-DIHYDRO-1,4-BENZODIAZEPINFORBINDELSER |
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