ANALOGIFREMGANGSMAATE FOR FREMSTILLING AV TERAPUTISK AKTIVE 2-ACYLAMINOMETHYL-1H-2,3-DIHYDRO-1,4-BENZODIAZEPIN-FORBINDELSER

New 2-acylaminomethyl-1H-2,3-dihydro-1,4-benzodiazepine compounds are described having the general formula I I wherein R1 is a hydrogen atom or a lower alkyl or alkenyl radical or the cyclopropylmethyl radical, R2 is a hydrogen atom, n is 0, 1 or 2, R3 is an optionally substituted furyl, thienyl, py...

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Hauptverfasser: ZEUGNER, HORST, ROEMER, DIETMAR, BENSON, WERNER, MILKOWSKI, WOLFGANG, LIEPMANN, HANS
Format: Patent
Sprache:nor
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Zusammenfassung:New 2-acylaminomethyl-1H-2,3-dihydro-1,4-benzodiazepine compounds are described having the general formula I I wherein R1 is a hydrogen atom or a lower alkyl or alkenyl radical or the cyclopropylmethyl radical, R2 is a hydrogen atom, n is 0, 1 or 2, R3 is an optionally substituted furyl, thienyl, pyrrolyl, pyridyl or phenyl radical, R4 is an optionally substituted furyl, thienyl or, pyrrolyl radical, R5 is a hydrogen or halogen atom, or a lower alkyl, lower alkoxy, hydroxyl, lower alkylthio, nitro, trifuloromethyl, cyano, amino, lower mono- or dialkylamino, lower monoalkanoylamino, lower N-alkyl-N-alkanoylamino or lower alkanoyloxy radical, and R6 is a hydrogen atom, or a lower alkyl or lower alkoxy radical or R5 and R6 together denote a methylenedioxy or ethylenedioxy radical. The compounds have pharmacological, for example, analgesic, properties.