ANALOGIFREMGANGSMAATE VED FREMSTILLING AV TERAPEUTISK VIRKSOMME N-SUBSTITUERTE BENZAMIDDERIVATER

1508015 Piperidine and pyrrolidine derivatives RIKER LABORATORIES Inc 27 March 1975 [1 April 1974] 13027/75 Heading C2C Novel compounds I and IV wherein Rf=C 1-3 perfluoroalkyl, n=1, 2 or 3, p=1 or 2, Q=bond, methylene or ethylidene, and R and R1=H, Me or Et, provided that in compounds IV which contain a pyridine ring, R is absent, and pharmaceutically acceptable acid addition and quaternary ammonium salts of compounds I, are prepared by reacting a compound II with a compound of Formula III or III A in which Z is halogen or a RfCH 2 O- group and the other symbols have the meanings given above provided that in compounds IIIA which contain a pyridine ring, R is absent, and, if desired, hydrogenating a resulting compound IV to produce a compound I which may be subsequently methylated or ethylated in the 1- position, or converting a compound I into a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof. Pharmaceutical compositions having antiarrhythmic and anaesthetic activity, for oral, parenteral or topical administration, comprise a compound I or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof, together with a pharmaceutical carrier.