DEVICE AND METHOD FOR IN-VITRO TEST ON CALCIUM OSCILLATION OF NETWORK OF NEURONS

DEVICE AND METHOD FOR IN-VITRO TEST ON CALCIUM OSCILLATION OF NETWORK OF NEURONS

The invention discloses a device and method for in-vitro test on calcium oscillation of a network of neurons. The device includes a first module which is calcium signal testing and imaging equipment used for testing spontaneous calcium oscillation of cells, and a second, module which is calcium. sig...

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Hauptverfasser: XI CHEN, YE YANG, BINGBING CHEN, YALING YIN, XU ZHANG, DEJUN CHEN, ZHENZHOU SUN, FANFAN MA, YUE ZUO, RUIZHU YUE, YINGJUAN WEI, HONGWEI WANG
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Sprache:eng
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INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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creator XI CHEN
YE YANG
BINGBING CHEN
YALING YIN
XU ZHANG
DEJUN CHEN
ZHENZHOU SUN
FANFAN MA
YUE ZUO
RUIZHU YUE
YINGJUAN WEI
HONGWEI WANG
description The invention discloses a device and method for in-vitro test on calcium oscillation of a network of neurons. The device includes a first module which is calcium signal testing and imaging equipment used for testing spontaneous calcium oscillation of cells, and a second, module which is calcium. signal simulation. equipment for simulating a frequency and amplitude of a corresponding calcium oscillation of the first module. The method is based on the above- mentioned device. The concentration of intracellular calcium ions is tested on the basis of a calcium ion fluorescent probe and a calcium imaging technique. By adjusting changes in the concentration of extracellular fluid calcium ions, an intracellular calcium pool is stimulated to release calcium ions, so as to achieve an accurate simulation effect. Oscillatory waves of intracellular calcium ions with a certain frequency and amplitude under physiological and pathological conditions can be simulated.
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subjects INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
title DEVICE AND METHOD FOR IN-VITRO TEST ON CALCIUM OSCILLATION OF NETWORK OF NEURONS
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