Calibration of a chip-based microfluidic calorimeter

Calibration of a chip-based microfluidic calorimeter

The invention provides a calibration method for calibrating a chip-based microfluidic calorimeter (100), wherein the chip-based microfluidic calorimeter (100) comprises one or more thermopiles (110), wherein the calibration method uses the deprotonating reaction of a phosphate group, the method comp...

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Hauptverfasser: MORTEN VAN SCHIE, WILFRED RAYMOND HAGEN, PETER LEON HAGEDOORN, KOUROSH HONARMAND EBRAHIMI
Format: Patent
Sprache:eng
Schlagworte:
MEASURING
MEASURING QUANTITY OF HEAT
MEASURING TEMPERATURE
PHYSICS
TESTING
THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
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creator MORTEN VAN SCHIE
WILFRED RAYMOND HAGEN
PETER LEON HAGEDOORN
KOUROSH HONARMAND EBRAHIMI
description The invention provides a calibration method for calibrating a chip-based microfluidic calorimeter (100), wherein the chip-based microfluidic calorimeter (100) comprises one or more thermopiles (110), wherein the calibration method uses the deprotonating reaction of a phosphate group, the method comprising: providing calibration liquids (120) comprising (i) a buffer with a pH range of at least 7-9 and (ii) a first compound with a phosphate group which is protonated in a pH range of at least 3-6, and mixing these calibration liquids (120) in the chip-based microfluidic calorimeter (100) to provide a calibration liquid mixture (123) whereby heat is generated, measuring the heat by the thermopiles (110) and thereby providing a corresponding thermopile signal, and calibrating the chip-based microfluidic calorimeter (100) by relating the thermopile signal to reference data of the deprotonating reaction.
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subjects MEASURING
MEASURING QUANTITY OF HEAT
MEASURING TEMPERATURE
PHYSICS
TESTING
THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
title Calibration of a chip-based microfluidic calorimeter
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