DERIVADOS DE 5-[(PIPERAZINA-1-IL)-3-OXO-PROPIL]-IMIDAZOLIDINA-2,4-DIONA COMO INHIBIDORES ADAMTS PARA EL TRATAMIENTO DE LA OSTEOARTRITIS
La presente invención revela los compuestos según la Fórmula (I) en donde R, R2, R3a, R3b y Cy son como se definen en este documento. La presente invención revela compuestos inhibidores ADAMTS, métodos para su producción, composiciones farmacéuticas comprendiendo los mismos y métodos para la profila...
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| creator | HÉLÉNE MARIE JARY MARIE LAURENCE CLAIRE VARIN DAVID AMANTINI CHRISTOPHE PEIXOTO LUKE JONATHAN ALVEY PIERRE MARC MARIE JOSEPH DEPREZ FRÉDÉRIC ANDRÉ DE CEUNINCK FRANCK LAURENT BREBION ROMAIN LUC MARIE GOSMINI IULIANA ECATERINA POP-BOTEZ |
| description | La presente invención revela los compuestos según la Fórmula (I) en donde R, R2, R3a, R3b y Cy son como se definen en este documento. La presente invención revela compuestos inhibidores ADAMTS, métodos para su producción, composiciones farmacéuticas comprendiendo los mismos y métodos para la profilaxis y/o el tratamiento de condiciones inflamatorias y/o enfermedades que implican la degradación del cartilago y/o alteración de la homeostasis del cartílago.
The present invention discloses compounds according to formula I:Wherein R1, R2, R3a, R3b, and Cy are as defined herein.The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and the compounds of formula I for use in methods of treatment and for use in methods of prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis. |
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The present invention discloses compounds according to formula I:Wherein R1, R2, R3a, R3b, and Cy are as defined herein.The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and the compounds of formula I for use in methods of treatment and for use in methods of prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170908&DB=EPODOC&CC=NI&NR=201700081A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170908&DB=EPODOC&CC=NI&NR=201700081A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HÉLÉNE MARIE JARY</creatorcontrib><creatorcontrib>MARIE LAURENCE CLAIRE VARIN</creatorcontrib><creatorcontrib>DAVID AMANTINI</creatorcontrib><creatorcontrib>CHRISTOPHE PEIXOTO</creatorcontrib><creatorcontrib>LUKE JONATHAN ALVEY</creatorcontrib><creatorcontrib>PIERRE MARC MARIE JOSEPH DEPREZ</creatorcontrib><creatorcontrib>FRÉDÉRIC ANDRÉ DE CEUNINCK</creatorcontrib><creatorcontrib>FRANCK LAURENT BREBION</creatorcontrib><creatorcontrib>ROMAIN LUC MARIE GOSMINI</creatorcontrib><creatorcontrib>IULIANA ECATERINA POP-BOTEZ</creatorcontrib><title>DERIVADOS DE 5-[(PIPERAZINA-1-IL)-3-OXO-PROPIL]-IMIDAZOLIDINA-2,4-DIONA COMO INHIBIDORES ADAMTS PARA EL TRATAMIENTO DE LA OSTEOARTRITIS</title><description>La presente invención revela los compuestos según la Fórmula (I) en donde R, R2, R3a, R3b y Cy son como se definen en este documento. La presente invención revela compuestos inhibidores ADAMTS, métodos para su producción, composiciones farmacéuticas comprendiendo los mismos y métodos para la profilaxis y/o el tratamiento de condiciones inflamatorias y/o enfermedades que implican la degradación del cartilago y/o alteración de la homeostasis del cartílago.
The present invention discloses compounds according to formula I:Wherein R1, R2, R3a, R3b, and Cy are as defined herein.The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and the compounds of formula I for use in methods of treatment and for use in methods of prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzUEKwjAQQNFuXIh6h3Gn4EBrFd2OJtKBNBOSIFKRIhJXooLewWtLwQO4-psHv599lPa8JyUBlIYlHieOnfbUsCUskM0US5SDoPPi2JyQa1bUiGHViflsgYrFEmylFmBb8YaVeB2AFNUxgCNPoA1ET5Fq1jZKdzIEEqIW8tFz5DDMetfz7ZVGvw6y8U7HbYXp-WjT63m-pHt6t5bnebHK83xdUPmP-QKSsT1X</recordid><startdate>20170908</startdate><enddate>20170908</enddate><creator>HÉLÉNE MARIE JARY</creator><creator>MARIE LAURENCE CLAIRE VARIN</creator><creator>DAVID AMANTINI</creator><creator>CHRISTOPHE PEIXOTO</creator><creator>LUKE JONATHAN ALVEY</creator><creator>PIERRE MARC MARIE JOSEPH DEPREZ</creator><creator>FRÉDÉRIC ANDRÉ DE CEUNINCK</creator><creator>FRANCK LAURENT BREBION</creator><creator>ROMAIN LUC MARIE GOSMINI</creator><creator>IULIANA ECATERINA POP-BOTEZ</creator><scope>EVB</scope></search><sort><creationdate>20170908</creationdate><title>DERIVADOS DE 5-[(PIPERAZINA-1-IL)-3-OXO-PROPIL]-IMIDAZOLIDINA-2,4-DIONA COMO INHIBIDORES ADAMTS PARA EL TRATAMIENTO DE LA OSTEOARTRITIS</title><author>HÉLÉNE MARIE JARY ; MARIE LAURENCE CLAIRE VARIN ; DAVID AMANTINI ; CHRISTOPHE PEIXOTO ; LUKE JONATHAN ALVEY ; PIERRE MARC MARIE JOSEPH DEPREZ ; FRÉDÉRIC ANDRÉ DE CEUNINCK ; FRANCK LAURENT BREBION ; ROMAIN LUC MARIE GOSMINI ; IULIANA ECATERINA POP-BOTEZ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NI201700081A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HÉLÉNE MARIE JARY</creatorcontrib><creatorcontrib>MARIE LAURENCE CLAIRE VARIN</creatorcontrib><creatorcontrib>DAVID AMANTINI</creatorcontrib><creatorcontrib>CHRISTOPHE PEIXOTO</creatorcontrib><creatorcontrib>LUKE JONATHAN ALVEY</creatorcontrib><creatorcontrib>PIERRE MARC MARIE JOSEPH DEPREZ</creatorcontrib><creatorcontrib>FRÉDÉRIC ANDRÉ DE CEUNINCK</creatorcontrib><creatorcontrib>FRANCK LAURENT BREBION</creatorcontrib><creatorcontrib>ROMAIN LUC MARIE GOSMINI</creatorcontrib><creatorcontrib>IULIANA ECATERINA POP-BOTEZ</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HÉLÉNE MARIE JARY</au><au>MARIE LAURENCE CLAIRE VARIN</au><au>DAVID AMANTINI</au><au>CHRISTOPHE PEIXOTO</au><au>LUKE JONATHAN ALVEY</au><au>PIERRE MARC MARIE JOSEPH DEPREZ</au><au>FRÉDÉRIC ANDRÉ DE CEUNINCK</au><au>FRANCK LAURENT BREBION</au><au>ROMAIN LUC MARIE GOSMINI</au><au>IULIANA ECATERINA POP-BOTEZ</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>DERIVADOS DE 5-[(PIPERAZINA-1-IL)-3-OXO-PROPIL]-IMIDAZOLIDINA-2,4-DIONA COMO INHIBIDORES ADAMTS PARA EL TRATAMIENTO DE LA OSTEOARTRITIS</title><date>2017-09-08</date><risdate>2017</risdate><abstract>La presente invención revela los compuestos según la Fórmula (I) en donde R, R2, R3a, R3b y Cy son como se definen en este documento. La presente invención revela compuestos inhibidores ADAMTS, métodos para su producción, composiciones farmacéuticas comprendiendo los mismos y métodos para la profilaxis y/o el tratamiento de condiciones inflamatorias y/o enfermedades que implican la degradación del cartilago y/o alteración de la homeostasis del cartílago.
The present invention discloses compounds according to formula I:Wherein R1, R2, R3a, R3b, and Cy are as defined herein.The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and the compounds of formula I for use in methods of treatment and for use in methods of prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | DERIVADOS DE 5-[(PIPERAZINA-1-IL)-3-OXO-PROPIL]-IMIDAZOLIDINA-2,4-DIONA COMO INHIBIDORES ADAMTS PARA EL TRATAMIENTO DE LA OSTEOARTRITIS |
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