NUEVOS COMPUESTOS 578

La presente invención se refiere a nuevos compuestos de fórmula (I) y su composiciones farmacéuticas. Adicionalmente, la presente invención se refiere a métodos terapéuticos para el tratamiento y/o prevención de patologías relacionadas con Abeta tales como síndrome de Down, angiopatía 13-amiloide ta...

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Hauptverfasser: DIDIER ROTTICCI, STEFAN VON BERG, KARIN KOLMODIN, SOFIA KARLSTRÖM, JOHAN LINDSTRÖM, PETER SÖDERMAN, BRITT-MARIE SWAHN, LASZLO RAKOS, JÖRG HOLENZ
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creator DIDIER ROTTICCI
STEFAN VON BERG
KARIN KOLMODIN
SOFIA KARLSTRÖM
JOHAN LINDSTRÖM
PETER SÖDERMAN
BRITT-MARIE SWAHN
LASZLO RAKOS
JÖRG HOLENZ
description La presente invención se refiere a nuevos compuestos de fórmula (I) y su composiciones farmacéuticas. Adicionalmente, la presente invención se refiere a métodos terapéuticos para el tratamiento y/o prevención de patologías relacionadas con Abeta tales como síndrome de Down, angiopatía 13-amiloide tal como, a modo no taxativo, angiopatía amiloide cerebral o hemorragia cerebral hereditaria, trastornos asociados con deficiencia cognitiva tales como, a modo no taxativo, deterioro cognitivo leve, enfermedad de Alzheimer, pérdida de memoria, síntomas de déficit atencional asociados con la enfermedad de Alzheimer, neurodegeneración asociada con enfermedades tales como enfermedad de Alzheimer o demencia, incluyendo demencia de origen mixto vascular y degenerativo, demencia presenil, demencia senil y demencia asociada con la enfermedad de Parkinson, parálisis supranuclear progresiva o degeneración córtico-basal. The present invention relates to novel compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of A -related pathologies such as Downs syndrome, -amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer Disease, memory loss, attention deficit symptoms associated with Alzheimer disease, neurodegeneration associated with diseases such as Alzheimer disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title NUEVOS COMPUESTOS 578
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