ALGUNOS DERIVADOS DE 2-PIRAZINONA Y SU USO COMO INHIBIDORES DE ELASTASA DE LOS NEUTRÓFILOS
La invención proporciona ciertos nuevos derivados de 6 - heteroaril - 5 - metil - 3 - oxo - 4 - [ 3 - (trifluorometil)fenil] - 3,4 - dihidropirazina - 2 - carboxamida y sales farmacéuticamente aceptables de los mismos y formas particulares de los mismos; junto con procesos para su preparación, compo...
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| creator | HANS LÖNN MARTÍN LINDSJÖ DEBRA AINGE MICHAEL LUNDKVIST ANTONIOS NIKITIDIS MAGNUS MUNCK AF ROSENSCHÖLD JOHN PAVEY |
| description | La invención proporciona ciertos nuevos derivados de 6 - heteroaril - 5 - metil - 3 - oxo - 4 - [ 3 - (trifluorometil)fenil] - 3,4 - dihidropirazina - 2 - carboxamida y sales farmacéuticamente aceptables de los mismos y formas particulares de los mismos; junto con procesos para su preparación, composiciones farmacéuticas que los contienen y su uso en terapia. Los compuestos son inhibidores de la estasa de los neutrófilos humanos.
The invention provides certain novel compounds as listed in the specification and pharmaceutically acceptable salts thereof and particular Forms thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase. The present neutrophil elastase inhibitors include 6-[1-(4-Cyanophenyl)-1H-pyrazol-5-yl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide: |
| format | Patent |
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The invention provides certain novel compounds as listed in the specification and pharmaceutically acceptable salts thereof and particular Forms thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase. The present neutrophil elastase inhibitors include 6-[1-(4-Cyanophenyl)-1H-pyrazol-5-yl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide:</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110324&DB=EPODOC&CC=NI&NR=201000079A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110324&DB=EPODOC&CC=NI&NR=201000079A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HANS LÖNN</creatorcontrib><creatorcontrib>MARTÍN LINDSJÖ</creatorcontrib><creatorcontrib>DEBRA AINGE</creatorcontrib><creatorcontrib>MICHAEL LUNDKVIST</creatorcontrib><creatorcontrib>ANTONIOS NIKITIDIS</creatorcontrib><creatorcontrib>MAGNUS MUNCK AF ROSENSCHÖLD</creatorcontrib><creatorcontrib>JOHN PAVEY</creatorcontrib><title>ALGUNOS DERIVADOS DE 2-PIRAZINONA Y SU USO COMO INHIBIDORES DE ELASTASA DE LOS NEUTRÓFILOS</title><description>La invención proporciona ciertos nuevos derivados de 6 - heteroaril - 5 - metil - 3 - oxo - 4 - [ 3 - (trifluorometil)fenil] - 3,4 - dihidropirazina - 2 - carboxamida y sales farmacéuticamente aceptables de los mismos y formas particulares de los mismos; junto con procesos para su preparación, composiciones farmacéuticas que los contienen y su uso en terapia. Los compuestos son inhibidores de la estasa de los neutrófilos humanos.
The invention provides certain novel compounds as listed in the specification and pharmaceutically acceptable salts thereof and particular Forms thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase. The present neutrophil elastase inhibitors include 6-[1-(4-Cyanophenyl)-1H-pyrazol-5-yl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide:</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZIh29HEP9fMPVnBxDfIMc3QBsxSMdAM8gxyjPP38_RwVIhWCQxVCg_0VnP19_RU8_Tw8nTxd_INcwSpdfRyDQxyDHUFsH6BmP9fQkKDDk908gRweBta0xJziVF4ozc2g6OYa4uyhm1qQH59aXJCYnJqXWhLv52lkYGgABOaWjsbEqAEAntMydg</recordid><startdate>20110324</startdate><enddate>20110324</enddate><creator>HANS LÖNN</creator><creator>MARTÍN LINDSJÖ</creator><creator>DEBRA AINGE</creator><creator>MICHAEL LUNDKVIST</creator><creator>ANTONIOS NIKITIDIS</creator><creator>MAGNUS MUNCK AF ROSENSCHÖLD</creator><creator>JOHN PAVEY</creator><scope>EVB</scope></search><sort><creationdate>20110324</creationdate><title>ALGUNOS DERIVADOS DE 2-PIRAZINONA Y SU USO COMO INHIBIDORES DE ELASTASA DE LOS NEUTRÓFILOS</title><author>HANS LÖNN ; MARTÍN LINDSJÖ ; DEBRA AINGE ; MICHAEL LUNDKVIST ; ANTONIOS NIKITIDIS ; MAGNUS MUNCK AF ROSENSCHÖLD ; JOHN PAVEY</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NI201000079A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2011</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HANS LÖNN</creatorcontrib><creatorcontrib>MARTÍN LINDSJÖ</creatorcontrib><creatorcontrib>DEBRA AINGE</creatorcontrib><creatorcontrib>MICHAEL LUNDKVIST</creatorcontrib><creatorcontrib>ANTONIOS NIKITIDIS</creatorcontrib><creatorcontrib>MAGNUS MUNCK AF ROSENSCHÖLD</creatorcontrib><creatorcontrib>JOHN PAVEY</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HANS LÖNN</au><au>MARTÍN LINDSJÖ</au><au>DEBRA AINGE</au><au>MICHAEL LUNDKVIST</au><au>ANTONIOS NIKITIDIS</au><au>MAGNUS MUNCK AF ROSENSCHÖLD</au><au>JOHN PAVEY</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ALGUNOS DERIVADOS DE 2-PIRAZINONA Y SU USO COMO INHIBIDORES DE ELASTASA DE LOS NEUTRÓFILOS</title><date>2011-03-24</date><risdate>2011</risdate><abstract>La invención proporciona ciertos nuevos derivados de 6 - heteroaril - 5 - metil - 3 - oxo - 4 - [ 3 - (trifluorometil)fenil] - 3,4 - dihidropirazina - 2 - carboxamida y sales farmacéuticamente aceptables de los mismos y formas particulares de los mismos; junto con procesos para su preparación, composiciones farmacéuticas que los contienen y su uso en terapia. Los compuestos son inhibidores de la estasa de los neutrófilos humanos.
The invention provides certain novel compounds as listed in the specification and pharmaceutically acceptable salts thereof and particular Forms thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase. The present neutrophil elastase inhibitors include 6-[1-(4-Cyanophenyl)-1H-pyrazol-5-yl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide:</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ALGUNOS DERIVADOS DE 2-PIRAZINONA Y SU USO COMO INHIBIDORES DE ELASTASA DE LOS NEUTRÓFILOS |
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