6,7-DIAL KOXY-4(4-SUBSTITUTED-PIPERIDINO)-QUINAZOLINES

6,7-Dialkoxy-4-[4-(substituted)piperidino]quinazolines wherein the 4-substituent is -(CHR1)m-Z wherein R1 is hydrogen or lower alkyl; m is 1 or 2, with the proviso that when m is 2, each R1 can be the same or different; Z is -N(R2)COR3, -OCONR4R5, N(R2)SO2R3 or -N(R2)CONR4R5 wherein R2 is hydrogen o...

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Hauptverfasser: JOHN KENDRICK STUBBS, JOHN CHRISTOPHER DANILE WKZ, SIMON FRASER CAMPBELL, ALLAN LESLIE HAM
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creator JOHN KENDRICK STUBBS
JOHN CHRISTOPHER DANILE WKZ
SIMON FRASER CAMPBELL
ALLAN LESLIE HAM
description 6,7-Dialkoxy-4-[4-(substituted)piperidino]quinazolines wherein the 4-substituent is -(CHR1)m-Z wherein R1 is hydrogen or lower alkyl; m is 1 or 2, with the proviso that when m is 2, each R1 can be the same or different; Z is -N(R2)COR3, -OCONR4R5, N(R2)SO2R3 or -N(R2)CONR4R5 wherein R2 is hydrogen or lower alkyl; R3 is lower alkyl, benzyl or phenyl; and each of R4 and R5 is hydrogen or is selected from group R3; and methods for their preparation. The compounds are phosphodiesterase inhibitors and cardiac stimulants.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title 6,7-DIAL KOXY-4(4-SUBSTITUTED-PIPERIDINO)-QUINAZOLINES
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