DEUTERATED TRIAZOLOPYRIDAZINE AS A KINASE MODULATOR
The invention is directed to a triazolopyridazine compound of formula (I), N- oxides, pharmaceutically acceptable salts and solvates thereof, wherein D represents deuterium, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compoun...
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| creator | MEERPOEL, Lieven PERERA, Timothy, Pietro, Suren GILISSEN, Ronaldus, Arnodus, Hendrika, Joseph PYE, Philip, James HOUPIS, Ioannis, Nicolaos FURER, Patrick, Blasius |
| description | The invention is directed to a triazolopyridazine compound of formula (I), N- oxides, pharmaceutically acceptable salts and solvates thereof, wherein D represents deuterium, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders. |
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| title | DEUTERATED TRIAZOLOPYRIDAZINE AS A KINASE MODULATOR |
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