OXIDIZED AVIDIN WITH HIGH RESIDENCY TIME IN THE TREATED TISSUES
THE PRESENT INVENTION DESCRIBES CHEMICALLY MODIFIED AVIDINS THAT HAVE HIGHER PERMANENCE IN TREATED TISSUES COMPARED TO WILD TYPE AVIDIN. AVIDIN OXIDATION IS PERFORMED BY PERIODATE INCUBATION IN THE PRESENCE OF THE LOW AFFINITY LIGAND HABA WHICH, OCCUPYING THE BIOTIN BINDING SITES, PREVENTS PROTEIN D...
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