METHOD FOR PRODUCING INSULIN ANALOGS HAVING A DIBASIC B CHAIN TERMINUS

METHOD FOR PRODUCING INSULIN ANALOGS HAVING A DIBASIC B CHAIN TERMINUS

THE INVENTION RELATES TO A METHOD FOR PRODUCING A TYPE OF INSULIN BY GENETICALLY ENGINEERING A PRECURSOR THEREOF AND CONVERTING SAID PRECURSOR TO THE RESPECTIVE INSULIN IN A ENZYME-CATALYZED LIGATION REACTION WITH LYSINE AMIDE OR ARGININE AMIDE, OR BY LYSINE OR ARGININE WHICH IS MODIFIED BY PROTECTI...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HABERMANN, PAUL, ZOCHER, FRANK
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:THE INVENTION RELATES TO A METHOD FOR PRODUCING A TYPE OF INSULIN BY GENETICALLY ENGINEERING A PRECURSOR THEREOF AND CONVERTING SAID PRECURSOR TO THE RESPECTIVE INSULIN IN A ENZYME-CATALYZED LIGATION REACTION WITH LYSINE AMIDE OR ARGININE AMIDE, OR BY LYSINE OR ARGININE WHICH IS MODIFIED BY PROTECTIVE GROUPS, AND OPTIONALLY SUBSEQUENT HYDROLYSIS.