NON STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS

-38- NON STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS ABSTRACT THE PRESENT INVENTION RELATES TO COMPOUNDS HAVING GENERAL FORMULA I R9 R11 R12 13 14 R7 R13 R14 R4 R1 R3 2 5 FORMULA I OR A PHANNACCUTICALLY ACCEPTABLE SALT THEREOF. IN THIS 11ORINULA RI IS 14 OR (I -4C)AIKV]; R, IS -C(O)R]5OR-S(0)2RI5; R3 IS 14, (1-4C)ALKYL OR -OR16; R4 IS H, (14C)ALKN I OR -OR16, R6 IS H OR -C(II)NOR16: R7 IS H OR HALOGEN, CYANO; (1-6C)ALKYL, (2-6C)A1KENYL OR (2- 10 6C)ALKYNYL, ALL THREE OPTIONALLY SUBSTITUTED WITH 011. LIALOGEN OR NIL, -1-C(1A)NORI6, - OR16, -C(O)RI6, OR -C(O)OR16; R8 IS 14, CYANO, HALOGEN, NITRO; (1-6C) ALKY], (2- 6C)A1KENVI, (2-6C)ALKYNYL OR -0(1-6C)ALKYL, ALL OPTIONALLY SUBSTITUTED WITH ARNINO, HYDROXYL OR HALOGEN-, (LIETERO)ARV], OPTIONALLY SUBSTITUTED WITH CVUIO, HALOGEN, (I- 4C)ALK.Y], (1-4C)ALKOXV, (L-4QA1KOXY(I-4C)A1K-YI; -C(O)RJ81 -C(O)OR19, -C(O)NIIK17@ 1 5 -NI-1C(O)R2O, -C(1-4C)AJKYIN0R2I,- -C(I-I)NOR16, OR -NHS(O)2R,J@ R9 IS 11, HAIOGEN, CYANOOR(L-4QAIKVI OPTIONALLYSUBSTITUTED WITHLIALO-EN; RJOISJ-IOR(1-4QAIKV1; RIJ IS 14; R12 IS 1-1, CVANO OR (1-4C)ALKYL; R13 IS H, (1-4C)ALKYL, HALOGEN OR FORINYL-I R14 IS 11, I - HALOGEN, CYANO, (1-4C)ALKYL, (2-61C)ALKENYL, C(O)R21 OR (LIETEIO)ARYL; R15 IS LL@ 0- 6C)ALKYL, (2-6C)A1KENY), (2-6C)AIKYNVI,-O(2-6C)ALKYI, -O(2-6QA1KER)YI OR -0(2- 20 6C)ALKYNYL, ALL OPTIONALLY SUBSTITUTED WITH ONE OR INORE OH, HALOGEN, CYANO OR (HETEM)ARY], (HEICRO),LRY], OPTIONALLY SUBSTITUTED WITH (1-4C)ALKYL, HALOGEN, CYANO, NITRO OR ARNILLO, NI-12, (DI)(14C)ALKYLAININO, (I -4C)ALKYL(I -4C)ALK-OXYARNINE, (I- 4QA1KYL(HIO(L-4C)A1KVI OR (I-4C)A1KOXY(I-4C)AIKVL; R16 IS 11, (1-6C)ALKYL, (2- 6C),ILKENYL OR (2-6C).DK-YIIYL; R17 IS 1-1, (1-6C)ALK-VL, OPTIONALLY SUBSTITUTED WITH HALOOEN, 25 (14C)ALKOXY OR (HETERO)ARYL, OPTIONALLY SUBSTITUTED WITH HALOGEN, (14C)ALKYL OR (I- 4C)ALKOXY; (')-6C)CVCLOALKVF OR (HETERO)ARY], OPTIONALLY SUBSTITUTED WITH HALOGEN, (I- 4C)ALKYL OR (I -4C)ALKOXY , RI8 IS H, NIL,, C(O)R,I OR (1-4C)ALKYL, OPTIONALLY SUBSTITUTED