MONO-LYSINE SALTS OF AZOLE COMPOUNDS

MONO-LYSINE SALTS OF AZOLE COMPOUNDS

MONO-LYSINE SALTS OF TRIAZOLE COMPOUNDS HAVING A SECONDARY OR TERTIARY HYDROXY GROUP ARE PROVIDED. MORE PARTICULARLY, THE NEW WATER-SOLUBLE TRIAZOLE ANTIFUNGAL MONO-LYSINE SALT COMPOUNDS, OR SOLVATES THEREOF, ARE PROVIDED HAVING THE GENERAL FORMULA I: WHEREIN A IN FORMULA I REPRESENTS THE NON-HYDROX...

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Hauptverfasser: QI GAO, SUSANNE KIAU, BLISSE VAKKALAGADDA, MICHAEL G. FAKES, YADAGIRI R. PENDRI, CHUNG-PIN H. CHEN
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creator QI GAO
SUSANNE KIAU
BLISSE VAKKALAGADDA
MICHAEL G. FAKES
YADAGIRI R. PENDRI
CHUNG-PIN H. CHEN
description MONO-LYSINE SALTS OF TRIAZOLE COMPOUNDS HAVING A SECONDARY OR TERTIARY HYDROXY GROUP ARE PROVIDED. MORE PARTICULARLY, THE NEW WATER-SOLUBLE TRIAZOLE ANTIFUNGAL MONO-LYSINE SALT COMPOUNDS, OR SOLVATES THEREOF, ARE PROVIDED HAVING THE GENERAL FORMULA I: WHEREIN A IN FORMULA I REPRESENTS THE NON-HYDROXY PORTION OF A TRIAZOLE ANTIFUNGAL COMPOUND OF THE TYPE CONTAINING A SECONDARY OR TERTIARY HYDROXYL GROUP. RAND R1 IN FORMULA I CAN EACH BE A HYDROGEN ATOM OR AN ALKYL GROUP HAVING ONE TO SIX CARBON ATOMS. THE NOVEL WATER-SOLUBLE AZOLE COMPOUNDS ARE USEFUL FOR THE TREATMENT OF FUNGAL INFECTIONS AND CAN BE ADMINISTERED ORALLY, TOPICALLY AND PARENTERALLY.
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