ANTIBODIES AGAINST WEST NILE VIRUS AND THERAPEUTIC AND PROPHYLACTIC USES THEREOF

The present invention relates to compositions comprising antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV), and methods for preventing, treating or ameliorating symptoms associated with a flavivirus, particular...

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Bibliographische Detailangaben
Hauptverfasser:	THEODORE OLIPHANT, CHRISTOPHER MICHAEL DOANE, MICHAEL DIAMOND
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to compositions comprising antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV), and methods for preventing, treating or ameliorating symptoms associated with a flavivirus, particularly of West Nile Virus (WNV), infection utilizing said compositions. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with WNV infection, said methods comprising administering to a human subject an effective amount of one or more antibodies or fragments thereof that immunospecifically bind to a WNV antigen. The present invention also relates to detectable or diagnostic compositions comprising antibodies or fragments thereof that immunospecifically bind to a WNV antigen and methods for detecting or diagnosing WNV infection utilizing said compositions. La presente invencion se refiere a las composiciones que comprenden anticuerpos o fragmentos de los mismos que se enlazan inmunoespecificamente a uno o mas antigenos de un flavivirus, particularmente del virus del Nilo Occidental (WNV), y los metodos para prevenir, tratar o mejorar los sintomas asociados con una infeccion por flavivirus, particularmente del virus del Nilo Occidental (WNV) utilizando dichas composiciones. En particular, la presente invencion se refiere a los metodos para prevenir, tratar o mejorar los sintomas asociados con la infeccion por el WNV, los metodos comprenden administrarle a un sujeto humano una cantidad efectiva de uno o mas anticuerpos o fragmentos de los mismos que se enlazan inmunoespecificamente a un antigeno de WNV. La presente invencion tambien se refiere a las composiciones detectables o de diagnostico que comprenden los anticuerpos o fragmentos de los mismos que se enlazan inmunoespecificamente a un antigeno de WNV y los metodos para detectar o diagnosticar la infeccion por WNV, utilizando dichas composiciones.