DRUG DELIVERY SYSTEM BASED ON POLYETHYLENE VINYLACETATE COPOLYMERS

A drug delivery system consisting of one or more compartments and comprising a progestogenic compound dissolved in a thermoplastic polyethylene vinylacetate copolymer whereby, if the delivery system consists of one compartment, the compartment comprises (i) a core of a thermoplastic polyethylene vin...

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Hauptverfasser: JANNEKE SOPHIE GROEN, WOUTER DE GRAAFF, JOHANNES ANTONIUS HENDRIKUS VAN LAARHOVEN, RAYMOND ZEEMAN, MARC ANTON KRUFT, HERMAN VROMANS
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creator JANNEKE SOPHIE GROEN
WOUTER DE GRAAFF
JOHANNES ANTONIUS HENDRIKUS VAN LAARHOVEN
RAYMOND ZEEMAN
MARC ANTON KRUFT
HERMAN VROMANS
description A drug delivery system consisting of one or more compartments and comprising a progestogenic compound dissolved in a thermoplastic polyethylene vinylacetate copolymer whereby, if the delivery system consists of one compartment, the compartment comprises (i) a core of a thermoplastic polyethylene vinylacetate copolymer comprising the progestogenic compound, such progestogenic compound being dissolved in the polyethylene vinylacetate copolymer up to a concentration below the saturation level at 25 degree C, and an estrogenic compound; and (ii) a skin of a thermoplastic polyethylene vinylacetate copolymer covering the core, said skin being permeable for both compounds;- if the delivery system consists of more than one compartment, only one compartment comprises (iii) the progestogenic compound, such progestogenic compound being dissolved in a core of a thermoplastic polyethylene vinylacetate copolymer up to a concentration below the saturation level at 25 degree C, and an estrogenic compound; and (iv) a skin of a thermoplastic polyethylene vinylacetate copolymer covering the core, said skin being permeable for both compounds. Un sistema para el suministro de farmacos que consiste en uno o mas compartimientos y contiene un compuesto progestageno disuelto en un copolimero termoplastico de polietileno y acetato de vinilo, mediante el cual, si el sistema de suministro consiste en un compartimiento, el compartimiento contiene (i) un nucleo de un copolimero termoplastico de polietileno y acetato de vinilo, que contiene el compuesto progestageno, este compuesto progestageno esta disuelto en el copolimero de polietileno y acetato de vinilo hasta una concentracion por debajo del nivel de saturacion a 25 degree C y un compuesto estrogeno; y (ii) una piel de un copolimero termoplastico de polietileno y acetato de vinilo que cubre el nucleo, dicha piel es permeable para ambos compuestos; si el sistema de suministro consiste en mas de un compartimiento, solamente un compartimiento contiene (iii) el compuesto progestageno, este compuesto progestageno esta disuelto en un nucleo de un copolimero termoplastico de acetato de vinilo y polietileno hasta una concentracion por debajo del nivel de saturacion a 25 degree C, y un compuesto estrogeno; y (iv) una piel de un copolimero termoplastico de polietileno y acetato de vinilo que cubre el nucleo, dicha piel es permeable para ambos compuestos.
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and (ii) a skin of a thermoplastic polyethylene vinylacetate copolymer covering the core, said skin being permeable for both compounds;- if the delivery system consists of more than one compartment, only one compartment comprises (iii) the progestogenic compound, such progestogenic compound being dissolved in a core of a thermoplastic polyethylene vinylacetate copolymer up to a concentration below the saturation level at 25 degree C, and an estrogenic compound; and (iv) a skin of a thermoplastic polyethylene vinylacetate copolymer covering the core, said skin being permeable for both compounds. Un sistema para el suministro de farmacos que consiste en uno o mas compartimientos y contiene un compuesto progestageno disuelto en un copolimero termoplastico de polietileno y acetato de vinilo, mediante el cual, si el sistema de suministro consiste en un compartimiento, el compartimiento contiene (i) un nucleo de un copolimero termoplastico de polietileno y acetato de vinilo, que contiene el compuesto progestageno, este compuesto progestageno esta disuelto en el copolimero de polietileno y acetato de vinilo hasta una concentracion por debajo del nivel de saturacion a 25 degree C y un compuesto estrogeno; y (ii) una piel de un copolimero termoplastico de polietileno y acetato de vinilo que cubre el nucleo, dicha piel es permeable para ambos compuestos; si el sistema de suministro consiste en mas de un compartimiento, solamente un compartimiento contiene (iii) el compuesto progestageno, este compuesto progestageno esta disuelto en un nucleo de un copolimero termoplastico de acetato de vinilo y polietileno hasta una concentracion por debajo del nivel de saturacion a 25 degree C, y un compuesto estrogeno; y (iv) una piel de un copolimero termoplastico de polietileno y acetato de vinilo que cubre el nucleo, dicha piel es permeable para ambos compuestos.</abstract><oa>free_for_read</oa></addata></record>
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title DRUG DELIVERY SYSTEM BASED ON POLYETHYLENE VINYLACETATE COPOLYMERS
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