OSMOTIC DELIVERY SYSTEM
An osmotic pharmaceutical tablet is described which comprises a single-layer compressed core surrounded by a water permeable layer having a passageway. The single-layer core contains (i) a non-ripening drug having a solubility per dose less than about 1 mL-1, (ii) about 2.0% to about 20% by weight o...
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| Format: | Patent |
| Sprache: | eng ; spa |
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| Zusammenfassung: | An osmotic pharmaceutical tablet is described which comprises a single-layer compressed core surrounded by a water permeable layer having a passageway. The single-layer core contains (i) a non-ripening drug having a solubility per dose less than about 1 mL-1, (ii) about 2.0% to about 20% by weight of a hydroxyethylcellulose having a weight-average, molecular weight from about 300,000 to about 2,000,000, and (iii) an osmagent.
Se describe un comprimido farmaceutico osmotico que comprende un nucleo comprimido de capa sencilla rodeado por una capa permeable al agua que tiene un paso; el nucleo de capa sencilla contiene (i) un farmaco no madurador con una solubilidad por dosis menor que aproximadamente 1 ml-1, (ii) aproximadamente 2.0% a aproximadamente 20% en peso de una hidroxietilcelulosa con un peso molecular medio ponderal de aproximadamente 300,000 a aproximadamente 2,000,000 y (iii) un agente osmotico. |
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