AZOLES AS MALONYL-COA DECARBOXYLASE INHIBITORS USEFUL AS METABOLIC MODULATORS
The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to t...
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| creator | ROSSY SERAFIMOV |
| description | The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the formulae (I) and (II), wherein Y, C, R1, R2, R6, and R7 are defined herein.
La presente invencion se refiere a metodos para el tratamiento de ciertas enfermedades metabolicas, y a compuestos novedosos y sus farmacos, y/o sales farmaceuticamente aceptables, composiciones farmaceuticas que contienen tales compuestos utiles en el tratamiento de dichas enfermedades. En particular, esta invencion se refiere al uso de compuestos y composiciones novedosas para el tratamiento de enfermedades cardiovasculares, diabetes, canceres, acidosis y obesidad, a traves de la inhibicion de malonil-CoA-descarboxilasa (MCD). Estos compuestos tienen las formulas I y II, en donde Y, C, R1, R2, R6 y R7 se definen aqui. (ver formulas). |
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La presente invencion se refiere a metodos para el tratamiento de ciertas enfermedades metabolicas, y a compuestos novedosos y sus farmacos, y/o sales farmaceuticamente aceptables, composiciones farmaceuticas que contienen tales compuestos utiles en el tratamiento de dichas enfermedades. En particular, esta invencion se refiere al uso de compuestos y composiciones novedosas para el tratamiento de enfermedades cardiovasculares, diabetes, canceres, acidosis y obesidad, a traves de la inhibicion de malonil-CoA-descarboxilasa (MCD). Estos compuestos tienen las formulas I y II, en donde Y, C, R1, R2, R6 y R7 se definen aqui. (ver formulas).</description><edition>7</edition><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20041015&DB=EPODOC&CC=MX&NR=PA03007441A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20041015&DB=EPODOC&CC=MX&NR=PA03007441A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ROSSY SERAFIMOV</creatorcontrib><title>AZOLES AS MALONYL-COA DECARBOXYLASE INHIBITORS USEFUL AS METABOLIC MODULATORS</title><description>The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the formulae (I) and (II), wherein Y, C, R1, R2, R6, and R7 are defined herein.
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La presente invencion se refiere a metodos para el tratamiento de ciertas enfermedades metabolicas, y a compuestos novedosos y sus farmacos, y/o sales farmaceuticamente aceptables, composiciones farmaceuticas que contienen tales compuestos utiles en el tratamiento de dichas enfermedades. En particular, esta invencion se refiere al uso de compuestos y composiciones novedosas para el tratamiento de enfermedades cardiovasculares, diabetes, canceres, acidosis y obesidad, a traves de la inhibicion de malonil-CoA-descarboxilasa (MCD). Estos compuestos tienen las formulas I y II, en donde Y, C, R1, R2, R6 y R7 se definen aqui. (ver formulas).</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | AZOLES AS MALONYL-COA DECARBOXYLASE INHIBITORS USEFUL AS METABOLIC MODULATORS |
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