METHOD OF MAKING (S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID
A method of making (U)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with (II) to form primarily (III); reacting the (III) with a cyanide source to form (IV); decarboxylating the (IV) to form (V); hydrolyzing the (V) with an alkali or alkaline earth metal hydroxide...
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| creator | ROBERT DANIEL TITUS BRIAN KEITH HUCKABEE DENIS MARTIN SOBIERAY TODD MICHEL GROTE THOMAS MULHERN |
| description | A method of making (U)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with (II) to form primarily (III); reacting the (III) with a cyanide source to form (IV); decarboxylating the (IV) to form (V); hydrolyzing the (V) with an alkali or alkaline earth metal hydroxide to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (U)-3-(aminomethyl)-5-methylhexanoic acid, wherein R1 and R2 are the same or different and are hydrogen, C1-C6 alkyl, aryl, benzyl, or C3-C6 cycloalkyl. The present invention also provides a method of making (U)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with (II) to form primarily (III); reacting the (III) with a cyanide source to form (IV); decarboxylating the (IV) to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (U)-3-(aminomethyl)-5-methylhexanoic acid.
El compuesto que tiene la formula: 1 donde R1 y R2 son lo mismo o diferentes y son hidrogeno, C1-C6 alquilo, aril, benzil, o C3-C6 cicloalquilo. |
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El compuesto que tiene la formula: 1 donde R1 y R2 son lo mismo o diferentes y son hidrogeno, C1-C6 alquilo, aril, benzil, o C3-C6 cicloalquilo.</description><edition>6</edition><language>eng ; spa</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1998</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980630&DB=EPODOC&CC=MX&NR=9708652A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980630&DB=EPODOC&CC=MX&NR=9708652A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ROBERT DANIEL TITUS</creatorcontrib><creatorcontrib>BRIAN KEITH HUCKABEE</creatorcontrib><creatorcontrib>DENIS MARTIN SOBIERAY</creatorcontrib><creatorcontrib>TODD MICHEL GROTE</creatorcontrib><creatorcontrib>THOMAS MULHERN</creatorcontrib><title>METHOD OF MAKING (S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID</title><description>A method of making (U)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with (II) to form primarily (III); reacting the (III) with a cyanide source to form (IV); decarboxylating the (IV) to form (V); hydrolyzing the (V) with an alkali or alkaline earth metal hydroxide to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (U)-3-(aminomethyl)-5-methylhexanoic acid, wherein R1 and R2 are the same or different and are hydrogen, C1-C6 alkyl, aryl, benzyl, or C3-C6 cycloalkyl. The present invention also provides a method of making (U)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with (II) to form primarily (III); reacting the (III) with a cyanide source to form (IV); decarboxylating the (IV) to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (U)-3-(aminomethyl)-5-methylhexanoic acid.
El compuesto que tiene la formula: 1 donde R1 y R2 son lo mismo o diferentes y son hidrogeno, C1-C6 alquilo, aril, benzil, o C3-C6 cicloalquilo.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1998</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDydQ3x8HdR8HdT8HX09vRzV9AI1tQ11tVw9PX08wdJRvpo6prqQlgerhGOfv6ezgqOzp4uPAysaYk5xam8UJqbQd7NNcTZQze1ID8-tbggMTk1L7Uk3jfC0tzAwszUyNGYsAoAvuwnpw</recordid><startdate>19980630</startdate><enddate>19980630</enddate><creator>ROBERT DANIEL TITUS</creator><creator>BRIAN KEITH HUCKABEE</creator><creator>DENIS MARTIN SOBIERAY</creator><creator>TODD MICHEL GROTE</creator><creator>THOMAS MULHERN</creator><scope>EVB</scope></search><sort><creationdate>19980630</creationdate><title>METHOD OF MAKING (S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID</title><author>ROBERT DANIEL TITUS ; BRIAN KEITH HUCKABEE ; DENIS MARTIN SOBIERAY ; TODD MICHEL GROTE ; THOMAS MULHERN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX9708652A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>1998</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>ROBERT DANIEL TITUS</creatorcontrib><creatorcontrib>BRIAN KEITH HUCKABEE</creatorcontrib><creatorcontrib>DENIS MARTIN SOBIERAY</creatorcontrib><creatorcontrib>TODD MICHEL GROTE</creatorcontrib><creatorcontrib>THOMAS MULHERN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ROBERT DANIEL TITUS</au><au>BRIAN KEITH HUCKABEE</au><au>DENIS MARTIN SOBIERAY</au><au>TODD MICHEL GROTE</au><au>THOMAS MULHERN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD OF MAKING (S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID</title><date>1998-06-30</date><risdate>1998</risdate><abstract>A method of making (U)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with (II) to form primarily (III); reacting the (III) with a cyanide source to form (IV); decarboxylating the (IV) to form (V); hydrolyzing the (V) with an alkali or alkaline earth metal hydroxide to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (U)-3-(aminomethyl)-5-methylhexanoic acid, wherein R1 and R2 are the same or different and are hydrogen, C1-C6 alkyl, aryl, benzyl, or C3-C6 cycloalkyl. The present invention also provides a method of making (U)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with (II) to form primarily (III); reacting the (III) with a cyanide source to form (IV); decarboxylating the (IV) to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (U)-3-(aminomethyl)-5-methylhexanoic acid.
El compuesto que tiene la formula: 1 donde R1 y R2 son lo mismo o diferentes y son hidrogeno, C1-C6 alquilo, aril, benzil, o C3-C6 cicloalquilo.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY ORGANIC CHEMISTRY |
| title | METHOD OF MAKING (S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID |
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